Odontoblast TRPC5 channels signal cold pain in teeth

Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, Dahl A, Freichel M, Vlachova V, Brauchi S, Roza C, Boehm U, Clapham DE, Lennerz JK, Zimmermann K (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 7

Journal Issue: 13

DOI: 10.1126/sciadv.abf5567

Abstract

Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensing system and show that sensory transduction of cold stimuli in teeth requires odontoblasts. TRPC5 is a cold sensor in healthy teeth and, with TRPA1, is sufficient for cold sensing. The odontoblast appears as the direct site of TRPC5 cold transduction and provides a mechanism for prolonged cold sensing via TRPC5's relative sensitivity to intracellular calcium and lack of desensitization. Our data provide concrete functional evidence that equipping odontoblasts with the cold-sensor TRPC5 expands traditional odontoblast functions and renders it a previously unknown integral cellular component of the dental cold sensing system.

Authors with CRIS profile

Involved external institutions

Universidad Austral de Chile Chile (CL) Technische Universität Dresden Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Washington University United States (USA) (US) Academy of Sciences of the Czech Republic (ASCR) / Akademie věd České republiky (AVČR) Czech Republic (CZ) Universidad de Alcalá (UAH) Spain (ES) Universität des Saarlandes (UdS) Germany (DE) University of Liège (ULg) / Université de Liège Belgium (BE) Boston Children's Hospital United States (USA) (US) Harvard University United States (USA) (US)

How to cite

APA:

Bernal, L., Sotelo-Hitschfeld, P., König, C., Sinica, V., Wyatt, A., Winter, Z.,... Zimmermann, K. (2021). Odontoblast TRPC5 channels signal cold pain in teeth. Science Advances, 7(13). https://dx.doi.org/10.1126/sciadv.abf5567

MLA:

Bernal, Laura, et al. "Odontoblast TRPC5 channels signal cold pain in teeth." Science Advances 7.13 (2021).

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