Rath T, Neurath M, Atreya R (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Book Volume: 23
Pages Range: 87-98
Journal Issue: 1
DOI: 10.1016/j.tige.2020.09.003
During the past decade, molecular imaging has emerged as a new and innovative field combining clinical endoscopy with methods prior used in basic science. Through the labeling of cellular targets with certain molecular probes and their subsequent detection with dedicated endoscopic devices, molecular imaging enables the visualization of single molecules or receptors during ongoing endoscopy. Early studies in the field have provided proof-of-principle that molecular imaging can improve visualization, or even unmask, previously unrecognized early dysplasia or cancer. Building on this, further studies then used molecular imaging for grading and detecting inflammation and inflammation associated cancer. Most recently, molecular imaging has been used to phenotype the expression of single receptors and targets of biological therapy and thereby enables molecular tissue profile in vivo. With this live molecular fingerprinting, molecular imaging can be used to guide expression-tailored individualized therapy, and due to the diversification of biological therapy in both cancer and intestinal inflammation, it can be expected that molecular imaging will gain further traction in the foreseeable future. Within this review, we first summarize the technical components commonly used for molecular imaging and then review preclinical and clinical studies and possible and evolving clinical applications on molecular imaging within the entire the GI tract.
APA:
Rath, T., Neurath, M., & Atreya, R. (2021). Molecular Imaging and its Applications in Selected GI Diseases. Techniques and Innovations in Gastrointestinal Endoscopy, 23(1), 87-98. https://doi.org/10.1016/j.tige.2020.09.003
MLA:
Rath, Timo, Markus Neurath, and Raja Atreya. "Molecular Imaging and its Applications in Selected GI Diseases." Techniques and Innovations in Gastrointestinal Endoscopy 23.1 (2021): 87-98.
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