Reliability and change in erosion measurements by high-resolution peripheral quantitative computed tomography in a longitudinal dataset of rheumatoid arthritis patients
Finzel S, Manske SL, Barnabe CC, Burghardt AJ, Marotte H, Scharmga A, Hauge EM, Chapurlat R, Engelke K, Li X, van Teeffelen BC, Conaghan PG, Stok KS (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 48
Pages Range: 348-351
Journal Issue: 3
Abstract
Objective. The aim of this multireader exercise was to assess the reliability and change over time of erosion measurements in patients with rheumatoid arthritis (RA) using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods. HR-pQCT scans of 23 patients with RA were assessed at baseline and 12 months. Four experienced readers examined the dorsal, palmar, radial, and ulnar surfaces of the metacarpal head (MH) and phalangeal base (PB) of the second and third digits, blinded to time order. In total, 368 surfaces (23 patients' 16 surfaces) were evaluated per timepoint to characterize cortical breaks as pathological (erosion) or physiological, and to quantify erosion width and depth. Reliability was evaluated by intraclass correlation coefficients (ICC), percentage agreement, and Light k; change over time was defined by means ± SD of erosion numbers and dimensions. Results. ICC for the mean measurements of width and depth of the pathological breaks ranged between 0.819-0.883, and 0.771-0.907, respectively. Most physiological cortical breaks were found at the palmar PB, whereas most pathological cortical breaks were located at the radial MH. There was a significant increase in both the numbers and the dimensions of erosions between baseline and follow-up (P = 0.0001 for erosion numbers, width, and depth in axial plane; P = 0.001 for depth in perpendicular plane). Conclusion. This exercise confirmed good reliability of HR-pQCT erosion measurements and their ability to detect change over time.
Authors with CRIS profile
Additional Organisation(s)
Involved external institutions
Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich
Switzerland (CH)
Université de Lyon (UDL)
France (FR)
University of Calgary
Canada (CA)
The University of Melbourne
Australia (AU)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Cleveland Clinic
United States (USA) (US)
University of Leeds
United Kingdom (GB)
Aarhus University Hospital / Aarhus Universitetshospital
Denmark (DK)
University of California San Francisco (UCSF)
United States (USA) (US)
Hôpital Edouard Herriot
France (FR)
Maastricht University
Netherlands (NL)
Switzerland (CH)
Université de Lyon (UDL)
France (FR)
University of Calgary
Canada (CA)
The University of Melbourne
Australia (AU)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Cleveland Clinic
United States (USA) (US)
University of Leeds
United Kingdom (GB)
Aarhus University Hospital / Aarhus Universitetshospital
Denmark (DK)
University of California San Francisco (UCSF)
United States (USA) (US)
Hôpital Edouard Herriot
France (FR)
Maastricht University
Netherlands (NL)
How to cite
APA:
Finzel, S., Manske, S.L., Barnabe, C.C., Burghardt, A.J., Marotte, H., Scharmga, A.,... Stok, K.S. (2021). Reliability and change in erosion measurements by high-resolution peripheral quantitative computed tomography in a longitudinal dataset of rheumatoid arthritis patients. Journal of Rheumatology, 48(3), 348-351. https://doi.org/10.3899/JRHEUM.191391
MLA:
Finzel, Stephanie, et al. "Reliability and change in erosion measurements by high-resolution peripheral quantitative computed tomography in a longitudinal dataset of rheumatoid arthritis patients." Journal of Rheumatology 48.3 (2021): 348-351.
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