Transforming growth factor-beta 1 is a negative modulator of adult neurogenesis
Winner B, Couillard-Despres S, Winkler J, Bogdahn U (2006)
Publication Status: Published
Publication Type: Journal article
Publication year: 2006
Journal
Publisher: OXFORD UNIV PRESS INC
Book Volume: 65
Pages Range: 358-370
Journal Issue: 4
DOI: 10.1097/01.jnen.0000218444.53405.f0
Abstract
Transforming growth factor (TGF)-beta 1 has multiple functions in the adult central nervous system (CNS). It modulates inflammatory responses in the CNS and controls proliferation of microglia and astrocytes. In the diseased brain, TGF-beta 1 expression is upregulated and, depending on the cellular context, its activity can be beneficial or detrimental regarding regeneration. We focus on the role of TGF-beta 1 in adult neural stem cell biology and neurogenesis. In adult neural stem and progenitor cell cultures and after intracerebroventricular infusion, TGF-beta 1 induced a long-lasting inhibition of neural stem and progenitor cell proliferation and a reduction in neurogenesis. In vitro, although TGF-beta 1 specifically arrested neural stem and progenitor cells in the G0/1 phase of the cell cycle, it did not affect the self-renewal capacity and the differentiation fate of these cells. Also, in vivo, TGF-beta 1 did not influence the differentiation fate of newly generated cells as shown by bromo-deoxyuridine incorporation experiments. Based on these data, we suggest that TGF-beta 1 is an important signaling molecule involved in the control of neural stem and progenitor cell proliferation in the CNS. This might have potential implications for neurogenesis in a variety of TGF-beta 1-associated CNS diseases and pathologic conditions.
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Germany (DE)
Austria (AT)How to cite
APA:
Winner, B., Couillard-Despres, S., Winkler, J., & Bogdahn, U. (2006). Transforming growth factor-beta 1 is a negative modulator of adult neurogenesis. Journal of Neuropathology and Experimental Neurology, 65(4), 358-370. https://doi.org/10.1097/01.jnen.0000218444.53405.f0
MLA:
Winner, Beate, et al. "Transforming growth factor-beta 1 is a negative modulator of adult neurogenesis." Journal of Neuropathology and Experimental Neurology 65.4 (2006): 358-370.
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