Cell-based endometrial regeneration: current status and future perspectives
Keyhanvar N, Zarghami N, Bleisinger N, Hajipour H, Fattahi A, Nouri M, Dittrich R (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
DOI: 10.1007/s00441-021-03419-6
Abstract
Endometrial-related disorders including Asherman's syndrome, thin endometrium, pelvic organ prolapse, and cesarean scar pregnancies can be accompanied by different symptoms such as amenorrhea, infertility, abnormal placental implantation and recurrent miscarriage. Different methods have been introduced to overcome these problems such as surgery and hormonal therapy but none of them has shown promising outcomes. On the other hand, the development of novel regenerative therapeutic strategies has opened new avenues for the treatment of endometrial-related deficiencies. In this regard, different types of scaffolds, acellular matrices and also cell therapy with adult or stem cells have been investigated for the treatment of endometrial-related deficiencies. In this paper, we review the current status of cell-based endometrium regeneration using scaffold dependent and scaffold-free methods and future perspectives in this field. Moreover, we discuss the endometrial diseases that can be candidates for cell-based treatments. Also, the cells with the potential for endometrial regeneration are explained.
Authors with CRIS profile
Nathalie Bleisinger
Department of Obstetrics and Gynaecology
Ralf Dittrich
Professur für Experimentelle Reproduktionsmedizin
Involved external institutions
Iran, Islamic Republic of (IR)How to cite
APA:
Keyhanvar, N., Zarghami, N., Bleisinger, N., Hajipour, H., Fattahi, A., Nouri, M., & Dittrich, R. (2021). Cell-based endometrial regeneration: current status and future perspectives. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03419-6
MLA:
Keyhanvar, Neda, et al. "Cell-based endometrial regeneration: current status and future perspectives." Cell and Tissue Research (2021).
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