Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)

Widder M, Mierzwa L, Schwerg L, Schecke H, Kornhuber J, Bouna-Pyrrou P, Bumb JM, Richter-Schmidinger T, Lenz B (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 11

Article Number: 5233

Journal Issue: 1

DOI: 10.1038/s41598-021-83942-2

Abstract

Alcohol consumption during pregnancy may lead to permanent damage in the offspring, including fetal alcohol spectrum disorders (FASD), which have an estimated prevalence of 1–8% worldwide. In adulthood, diagnosing FASD is time-consuming and costly. This study aimed to evaluate the discriminatory power of a German screening instrument for FASD in adults—the biographic screening interview (BSI-FASD). In an open-label comparative cohort study wherein a one-time survey was administered per participant, we compared 22 subjects with confirmed FASD with control groups of 15 subjects diagnosed with attention deficit hyperactivity disorder (ADHD), 20 subjects with alcohol or opiate dependence, 18 subjects with depression, and 31 controls without prenatal alcohol exposure. The BSI-FASD was found to be resource-efficient, user-friendly, comprehensible, and easily applicable. It provided an overall good convergent and discriminant validity with a sensitivity of 0.77 (adapted 0.86) and specificities between 0.70 and 1.00. The BSI-FASD subdomains differed in their power to differentiate FASD from the groups. This study established that the BSI-FASD is an efficient instrument to screen adults with suspected FASD. The BSI-FASD may facilitate future diagnostic evaluation and thereby contribute to improved treatment of affected individuals.

Authors with CRIS profile

Michael Widder Department of Psychiatry and Psychotherapy Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie Polyxeni Bouna-Pyrrou Lehrstuhl für Psychiatrie und Psychotherapie Bernd Lenz Medizinische Fakultät

Involved external institutions

Evangelischer Verein Sonnenhof e.V. DE Germany (DE) Universitätsklinikum Mannheim DE Germany (DE) Universität Duisburg-Essen (UDE) DE Germany (DE)

How to cite

APA:

Widder, M., Mierzwa, L., Schwerg, L., Schecke, H., Kornhuber, J., Bouna-Pyrrou, P.,... Lenz, B. (2021). Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD). Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-83942-2

MLA:

Widder, Michael, et al. "Evaluation of the German biographic screening interview for fetal alcohol spectrum disorder (BSI-FASD)." Scientific Reports 11.1 (2021).

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