Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers

Glubb DM, Thompson DJ, Aben KKH, Alsulimani A, Amant F, Annibali D, Attia J, Barricarte A, Beckmann M, Berchuck A, Bermisheva M, Bernardini MQ, Bischof K, Bjorge L, Bodelon C, Brand AH, Brenton JD, Brinton LA, Bruinsma F, Buchanan DD, Burghaus S, Butzow R, Cai H, Carney ME, Chanock SJ, Chen C, Chen XQ, Chen Z, Cook LS, Cunningham JM, De Vivo I, Defazio A, Doherty JA, Dork T, Du Bois A, Dunning AM, Durst M, Edwards T, Edwards RP, Ekici AB, Ewing A, Fasching P, Ferguson S, Flanagan JM, Fostira F, Fountzilas G, Friedenreich CM, Gao B, Gaudet MM, Gawelko J, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harris HR, Harter P, Hein A, Heitz F, Hildebrandt MAT, Hillemanns P, Hogdall E, Hogdall CK, Holliday EG, Huntsman DG, Huzarski T, Jakubowska A, Jensen A, Jones ME, Karlan BY, Karnezis A, Kelley JL, Khusnutdinova E, Killeen JL, Kjaer SK, Klapdor R, Kobel M, Konopka B, Konstantopoulou I, Kopperud RK, Koti M, Kraft P, Kupryjanczyk J, Lambrechts D, Larson MC, Le Marchand L, Lele S, Lester J, Li AJ, Liang D, Liebrich C, Lipworth L, Lissowska J, Lu L, Lu KH, Macciotta A, Mattiello A, May T, Mcalpine JN, Mcguire V, Mcneish IA, Menon U, Modugno F, Moysich KB, Nevanlinna H, Odunsi K, Olsson H, Orsulic S, Osorio A, Palli D, Park-Simon TW, Pearce CL, Pejovic T, Permuth JB, Podgorska A, Ramus SJ, Rebbeck TR, Riggan MJ, Risch HA, Rothstein JH, Runnebaum IB, Scott RJ, Sellers TA, Senz J, Setiawan VW, Siddiqui N, Sieh W, Spiewankiewicz B, Sutphen R, Swerdlow AJ, Szafron LM, Teo SH, Thompson PJ, Thomsen LCV, Titus L, Tone A, Tumino R, Turman C, Vanderstichele A, Edwards DV, Vergote I, Vierkant RA, Wang Z, Wang-Gohrke S, Webb PM, White E, Whittemore AS, Winham SJ, Wu X, Wu AH, Yannoukakos D, Spurdle AB, O'Mara TA (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 30

Pages Range: 217-228

Journal Issue: 1

DOI: 10.1158/1055-9965.EPI-20-0739

Abstract

Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers.

Authors with CRIS profile

Involved external institutions

Roswell Park Cancer Institute United States (USA) (US) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) University of Cambridge United Kingdom (GB) National Cancer Institute (NCI) United States (USA) (US) Uniwersytet Rzeszowski Poland (PL) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) University of Pittsburgh United States (USA) (US) Mayo Clinic United States (USA) (US) American Cancer Society United States (USA) (US) Danish Cancer Society Research Center Denmark (DK) Cedars-Sinai Medical Center United States (USA) (US) University of Copenhagen Denmark (DK) University Health Network (UHN) Canada (CA) Alberta Health Services (AHS) Canada (CA) Beatson West of Scotland Cancer Centre (BWSCC) United Kingdom (GB) H. Lee Moffitt Cancer Center & Research Institute United States (USA) (US) The University of Melbourne Australia (AU) University College London (UCL) United Kingdom (GB) University of Texas MD Anderson Cancer Center United States (USA) (US) Cancer Council Victoria Australia (AU) Westmead Hospital Australia (AU) Haukeland University Hospital / Haukeland universitetssykehus Norway (NO) National Centre for Scientific Research (NCSR) "Demokritos" Greece (GR) Duke University Health System United States (USA) (US) University of Utah United States (USA) (US) University of British Columbia Canada (CA) Vanderbilt University United States (USA) (US) Kliniken Essen-Mitte Germany (DE) Universitätsklinikum Jena Germany (DE) Radboud University Nijmegen Netherlands (NL) Fred Hutchinson Cancer Research Center Canada (CA) University of South Florida (USF) United States (USA) (US) Glasgow Royal Infirmary (GRI) United Kingdom (GB) Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie Poland (PL) Stanford University United States (USA) (US) University of Hawaii (U.H.) United States (USA) (US) University of Southern California (USC) United States (USA) (US) Harvard University United States (USA) (US) Cancer Research Initiatives Foundation (CARIF) / Cancer Research Malaysia (CRM) Malaysia (MY) Dartmouth College United States (USA) (US) Yale University United States (USA) (US) Humboldt-Universität zu Berlin Germany (DE) John Hunter Hospital Australia (AU) Queen's University United Kingdom (GB) University of Calgary Canada (CA) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Russian Academy of Sciences / Росси́йская акаде́мия нау́к (RAS) Russian Federation (RU) The Institute of Cancer Research (ICR) United Kingdom (GB) Klinikum Wolfsburg Germany (DE) Texas Southern University (TSU) United States (USA) (US) Universitätsklinikum Ulm Germany (DE) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) Icahn School of Medicine at Mount Sinai United States (USA) (US) University of California Los Angeles (UCLA) United States (USA) (US) Ciber de Enfermedades Raras (CIBERER) Spain (ES) Helsingin yliopisto / University of Helsinki Finland (FI) Istituto per lo Studio e la Prevenzione Oncologica (ISPRO) Italy (IT) Lund University / Lunds universitet Sweden (SE) Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB) Belgium (BE) University of Washington United States (USA) (US) University of New South Wales (UNSW) Australia (AU) Oregon Health and Science University (OSHU) United States (USA) (US) UC Davis Medical Center United States (USA) (US) Università degli Studi di Napoli Federico II Italy (IT) University of Sydney (USYD) Australia (AU) University of New Mexico (UNM) / Universidad de Nuevo México United States (USA) (US) Brigham and Women's Hospital (BWH) United States (USA) (US) Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBER-ESP) Spain (ES) Aristotle University of Thessaloniki Greece (GR) University of Michigan United States (USA) (US)

How to cite

APA:

Glubb, D.M., Thompson, D.J., Aben, K.K.H., Alsulimani, A., Amant, F., Annibali, D.,... O'Mara, T.A. (2021). Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers. Cancer Epidemiology Biomarkers & Prevention, 30(1), 217-228. https://doi.org/10.1158/1055-9965.EPI-20-0739

MLA:

Glubb, Dylan M., et al. "Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers." Cancer Epidemiology Biomarkers & Prevention 30.1 (2021): 217-228.

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