A CD22-Shp1 phosphatase axis controls integrin beta(7) display and B cell function in mucosal immunity

Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocon B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC (2021)


Publication Type: Journal article

Publication year: 2021

Journal

DOI: 10.1038/s41590-021-00862-z

Abstract

Lymphocyte homing to the gut and Peyer's patches requires expression of integrin alpha(4)beta(7). Ballet and colleagues report that B cell expression of CD22 is required to specifically retain surface expression of beta(7) integrin molecules, thereby promoting B cell retention in the gut and optimal gut mucosal antibody responses.

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APA:

Ballet, R., Brennan, M., Brandl, C., Feng, N., Berri, J., Cheng, J.,... Butcher, E.C. (2021). A CD22-Shp1 phosphatase axis controls integrin beta(7) display and B cell function in mucosal immunity. Nature Immunology. https://dx.doi.org/10.1038/s41590-021-00862-z

MLA:

Ballet, Romain, et al. "A CD22-Shp1 phosphatase axis controls integrin beta(7) display and B cell function in mucosal immunity." Nature Immunology (2021).

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