PD1 expression and correlation with its ligands in oral cancer specimens and peripheral blood

Wehrhan F, Weber M, Baran C, Agaimy A, Büttner-Herold M, Kesting MR, Ries J (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Journal of Cranio-Maxillofacial Surgery Elsevier

Book Volume: 49

Pages Range: 118-125

Journal Issue: 2

DOI: 10.1016/j.jcms.2020.12.007

Abstract

Objectives: This study analyzed the expression of the PD1 receptor in tumor tissue and peripheral blood of oral squamous cell carcinoma (OSCC) patients, and correlated it with the PD1 ligands PD-L1 and PD-L2. The currently low response rates of checkpoint inhibitor treatment in OSCC could be increased by a better understanding of immune checkpoint biology. Despite evidence in the literature for upregulation of PD1 checkpoint ligands in OSCC tissue, there has been no correlation analysis of the PD1 receptor with its ligands in tissue specimens and peripheral blood of OSCC patients.

Authors with CRIS profile

Falk Wehrhan Department of Oral and Cranio-Maxillofacial Surgery Manuel Weber Department of Oral and Cranio-Maxillofacial Surgery Christoph Baran Department of Oral and Cranio-Maxillofacial Surgery Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Maike Büttner-Herold Department of Nephropathology Marco Rainer Kesting Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie Jutta Ries Medizinische Fakultät

How to cite

APA:

Wehrhan, F., Weber, M., Baran, C., Agaimy, A., Büttner-Herold, M., Kesting, M.R., & Ries, J. (2021). PD1 expression and correlation with its ligands in oral cancer specimens and peripheral blood. Journal of Cranio-Maxillofacial Surgery, 49(2), 118-125. https://doi.org/10.1016/j.jcms.2020.12.007

MLA:

Wehrhan, Falk, et al. "PD1 expression and correlation with its ligands in oral cancer specimens and peripheral blood." Journal of Cranio-Maxillofacial Surgery 49.2 (2021): 118-125.

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