Predicting prognosis of breast cancer patients with brain metastases in the BMBC registry—comparison of three different GPA prognostic scores

Riecke K, Müller V, Weide R, Schmidt M, Park‐simon TW, Möbus V, Mundhenke C, Polasik A, Lübbe K, Hesse T, Laakmann E, Thill M, Fasching P, Denkert C, Fehm T, Nekljudova V, Rey J, Loibl S, Witzel I (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Cancers MDPI

Book Volume: 13

Pages Range: 1-12

Article Number: 844

Journal Issue: 4

DOI: 10.3390/cancers13040844

Abstract

Several scores have been developed in order to estimate the prognosis of patients with brain metastases (BM) by objective criteria. The aim of this analysis was to validate all three published graded‐prognostic‐assessment (GPA)‐scores in a subcohort of 882 breast cancer (BC) patients with BM in the Brain Metastases in the German Breast Cancer (BMBC) registry. The median age at diagnosis of BM was 57 years. All in all, 22.3% of patients (n = 197) had triple‐negative, 33.4% (n = 295) luminal A like, 25.1% (n = 221) luminal B/HER2‐enriched like and 19.2% (n = 169) HER2 positive like BC. Age ≥60 years, evidence of extracranial metastases (ECM), higher number of BM, triple‐negative subtype and low Karnofsky‐Performance‐Status (KPS) were all associated with worse overall survival (OS) in univariate analysis (p < 0.001 each). All three GPA‐scores were associated with OS. The breast‐GPA showed the highest probability of classifying patients with survival above 12 months in the best prognostic group (specificity 68.7% compared with 48.1% for the updated breast‐GPA and 21.8% for the original GPA). Sensitivities for predicting 3 months survival were very low for all scores. In this analysis, all GPA‐scores showed only moderate diagnostic accuracy in predicting the OS of BC patients with BM.

Authors with CRIS profile

Christoph Mundhenke
Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Agaplesion Markus Krankenhaus DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) GBG Forschungs GmbH (German Breast Group) DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Agaplesion Diakonieklinikum Rotenburg DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE)

How to cite

APA:

Riecke, K., Müller, V., Weide, R., Schmidt, M., Park‐simon, T.W., Möbus, V.,... Witzel, I. (2021). Predicting prognosis of breast cancer patients with brain metastases in the BMBC registry—comparison of three different GPA prognostic scores. Cancers, 13(4), 1-12. https://doi.org/10.3390/cancers13040844

MLA:

Riecke, Kerstin, et al. "Predicting prognosis of breast cancer patients with brain metastases in the BMBC registry—comparison of three different GPA prognostic scores." Cancers 13.4 (2021): 1-12.

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