Schneidereit D, Broellochs A, Ritter P, Kreiß L, Mokhtari Z, Beilhack A, Krönke G, Ackermann J, Faas M, Grüneboom A, Schürmann S, Friedrich O (2021)
Publication Type: Journal article, Original article
Publication year: 2021
Book Volume: 11
Pages Range: 2876-2891
Journal Issue: 6
DOI: 10.7150/thno.51558
Rationale: Structural remodeling or damage as a result of disease or injury is often not evenly distributed throughout a tissue but strongly depends on localization and extent of damaging stimuli. Skeletal muscle as a mechanically active organ can express signs of local or even systemic myopathic damage, necrosis, or repair. Conventionally, muscle biopsies (patients) or whole muscles (animal models) are mechanically sliced and stained to assess structural alterations histologically. Three-dimensional tissue information can be obtained by applying deep imaging modalities, e.g. multiphoton or light-sheet microscopy. Chemical clearing approaches reduce scattering, e.g. through matching refractive tissue indices, to overcome optical penetration depth limits in thick tissues.
APA:
Schneidereit, D., Broellochs, A., Ritter, P., Kreiß, L., Mokhtari, Z., Beilhack, A.,... Friedrich, O. (2021). An advanced optical clearing protocol allows label-free detection of tissue necrosis via multiphoton microscopy in injured whole muscle. Theranostics, 11(6), 2876-2891. https://doi.org/10.7150/thno.51558
MLA:
Schneidereit, Dominik, et al. "An advanced optical clearing protocol allows label-free detection of tissue necrosis via multiphoton microscopy in injured whole muscle." Theranostics 11.6 (2021): 2876-2891.
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