All are Equal, Some are More Equal: Targeting IL 12 and 23 in IBD - A Clinical Perspective

Jefremow A, Neurath M (2020)


Publication Type: Journal article, Review article

Publication year: 2020

Journal

Book Volume: 9

Pages Range: 289-297

DOI: 10.2147/ITT.S282466

Abstract

Chronic inflammatory diseases like inflammatory bowel diseases (IBD) or psoriasis represents a worldwide health burden. Researchers provided great achievements in understanding the origin of these diseases leading to improved therapeutic options. The discovery of cytokines like tumor necrosis factor-a or transforming growth factor-beta are examples for these efforts. Interleukin 12 (IL 12) and interleukin 23 (IL 23) represent different important cytokines in this regard. They both belong to the interleukin 12 family and are related by sharing the subunit p40. Ustekinumab is an antibody that blocks p40 and thereby interleukins 12 and 23. Trials showed promising results in treating IBD patients with this drug. Consequently, new questions arose about the distinct features of IL 12 and 23. This review focuses on these interleukins regarding their functions in the healthy and inflamed gut and provides an overview about the results from in vitro and in vivo studies as well as clinical trials.

Authors with CRIS profile

How to cite

APA:

Jefremow, A., & Neurath, M. (2020). All are Equal, Some are More Equal: Targeting IL 12 and 23 in IBD - A Clinical Perspective. ImmunoTargets and Therapy, 9, 289-297. https://doi.org/10.2147/ITT.S282466

MLA:

Jefremow, Andre, and Markus Neurath. "All are Equal, Some are More Equal: Targeting IL 12 and 23 in IBD - A Clinical Perspective." ImmunoTargets and Therapy 9 (2020): 289-297.

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