Efficient and high accuracy 3-D OCT angiography motion correction in pathology

Ploner S, Kraus M, Moult EM, Husvogt L, Schottenhamml J, Yasin Alibhai A, Waheed NK, Duker JS, Fujimoto JG, Maier A (2021)

Publication Type: Journal article, Original article

Publication year: 2021


Book Volume: 12

Pages Range: 125-146

Journal Issue: 1

URI: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-125

DOI: 10.1364/BOE.411117

Open Access Link: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-125


We describe a novel method for non-rigid 3-D motion correction of orthogonally raster-scanned optical coherence tomography angiography volumes. This is the first approach that aligns predominantly axial structural features such as retinal layers as well as transverse angiographic vascular features in a joint optimization. Combined with orthogonal scanning and favorization of kinematically more plausible displacements, subpixel alignment and micrometer-scale distortion correction is achieved in all 3 dimensions. As no specific structures are segmented, the method is by design robust to pathologic changes. Furthermore, the method is designed for highly parallel implementation and short runtime, allowing its integration into clinical workflow even for high density or wide-field scans. We evaluated the algorithm with metrics related to clinically relevant features in an extensive quantitative evaluation based on 204 volumetric scans of 17 subjects, including patients with diverse pathologies and healthy controls. Using this method, we achieve state-of-the-art axial motion correction and show significant advances in both transverse co-alignment and distortion correction, especially in the subgroup with pathology.

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Ploner, S., Kraus, M., Moult, E.M., Husvogt, L., Schottenhamml, J., Yasin Alibhai, A.,... Maier, A. (2021). Efficient and high accuracy 3-D OCT angiography motion correction in pathology. Biomedical Optics Express, 12(1), 125-146. https://dx.doi.org/10.1364/BOE.411117


Ploner, Stefan, et al. "Efficient and high accuracy 3-D OCT angiography motion correction in pathology." Biomedical Optics Express 12.1 (2021): 125-146.

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