Palliativchirurgie beim kolorektalen Karzinom – welche Faktoren können bei der Wahl des operativen Vorgehens helfen?
Konopke R, Schubert J, Stoeltzing O, Thomas T, Kersting S, Denz A (2020)
Publication Type: Journal article
Publication year: 2020
Journal
DOI: 10.1055/a-1291-8293
Abstract
Background The surgical procedure for patients with colorectal cancer (CRC) in the palliative situation cannot be adequately standardised. The present study was initiated to identify criteria for the decision for resection of the malignancy with or without anastomosis. Patients/Material and Methods In a unicentric retrospective analysis, 103 patients after palliative resection with or without anastomosis due to CRC were examined. Using univariate and logistic regression analysis, the influence of a total of 40 factors on postoperative morbidity and mortality was assessed. Results In 46 cases, resection with primary anastomosis and in 57 cases a discontinuity resection was performed. Postoperative morbidity was 44.7% and mortality 17.5%. After one-stage resection with anastomosis, nicotine abuse (OR 4.2; p = 0.044), hypalbuminaemia (OR 4.0; p = 0.012), ASA score > 2 (OR 3.7; p = 0.030) and liver remodelling/cirrhosis (OR 3.6; p = 0.031) increased the risk for postoperative complications. Hypalbuminaemia (OR 1.8; p = 0.036), cachexia (OR 1.8; p = 0.043), anaemia (OR 1.5; p = 0.038) and known alcohol abuse (OR 1.9; p = 0.023) were identified as independent risk factors for early postoperative mortality. After discontinuity resection, renal failure (OR 2.1; p = 0.042) and cachexia (OR 1.5; p = 0.045) led to a significant increase in the risk of postoperative morbidity, alcohol abuse (OR 1.8; p = 0.041) in mortality. Hypalbuminaemia (OR 2.8; p = 0.019) and an ASA score > 2 (OR 2.6; p = 0.004) after resection and reconstruction increased the risk of major complications according to Clavien-Dindo, while pre-existing renal failure (OR 1.6; p = 0.023) increased the risk after discontinuity resection. In univariate analysis, an ASA score > 2 (p = 0.038) after simultaneous tumour resection and reconstruction, and urgent surgery in both groups with or without primary anastomosis were additionally identified as significant parameters with a negative influence on mortality (p = 0.010 and p = 0.017). Conclusion Palliative resections of colorectal carcinomas have high morbidity and mortality. Especially in cases of pre-existing alcohol abuse and/or urgent indication for surgery, more intensive monitoring should be performed. In the case of anaemia, cachexia, hypalbuminemia and an ASA score > 2, discontinuity resection may be the more appropriate procedure.
Involved external institutions
Germany (DE)How to cite
APA:
Konopke, R., Schubert, J., Stoeltzing, O., Thomas, T., Kersting, S., & Denz, A. (2020). Palliativchirurgie beim kolorektalen Karzinom – welche Faktoren können bei der Wahl des operativen Vorgehens helfen? Zentralblatt für Chirurgie. https://doi.org/10.1055/a-1291-8293
MLA:
Konopke, Ralf, et al. "Palliativchirurgie beim kolorektalen Karzinom – welche Faktoren können bei der Wahl des operativen Vorgehens helfen?" Zentralblatt für Chirurgie (2020).
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