Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro
Prasad B, Grimm D, Strauch SM, Erzinger GS, Corydon TJ, Lebert M, Magnusson NE, Infanger M, Richter P, Krüger M (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 21
Pages Range: 1-32
Article Number: 9373
Journal Issue: 24
DOI: 10.3390/ijms21249373
Abstract
All life forms have evolved under the constant force of gravity on Earth and developed ways to counterbalance acceleration load. In space, shear forces, buoyance-driven convection, and hydrostatic pressure are nullified or strongly reduced. When subjected to microgravity in space, the equilibrium between cell architecture and the external force is disturbed, resulting in changes at the cellular and sub-cellular levels (e.g., cytoskeleton, signal transduction, membrane permeability, etc.). Cosmic radiation also poses great health risks to astronauts because it has high linear energy transfer values that evoke complex DNA and other cellular damage. Space environmental conditions have been shown to influence apoptosis in various cell types. Apoptosis has important functions in morphogenesis, organ development, and wound healing. This review provides an overview of microgravity research platforms and apoptosis. The sections summarize the current knowledge of the impact of microgravity and cosmic radiation on cells with respect to apoptosis. Apoptosis-related microgravity experiments conducted with different mammalian model systems are presented. Recent findings in cells of the immune system, cardiovascular system, brain, eyes, cartilage, bone, gastrointestinal tract, liver, and pancreas, as well as cancer cells investigated under real and simulated microgravity conditions, are discussed. This comprehensive review indicates the potential of the space environment in biomedical research.
Authors with CRIS profile
Binod Prasad
Lehrstuhl für Zellbiologie
Michael Lebert
Lehrstuhl für Zellbiologie
Peter Richter
Lehrstuhl für Zellbiologie
Involved external institutions
Aarhus University
Denmark (DK)
Universidade da Região de Joinville (UNIVILLE)
Brazil (BR)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Denmark (DK)
Universidade da Região de Joinville (UNIVILLE)
Brazil (BR)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
How to cite
APA:
Prasad, B., Grimm, D., Strauch, S.M., Erzinger, G.S., Corydon, T.J., Lebert, M.,... Krüger, M. (2020). Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro. International Journal of Molecular Sciences, 21(24), 1-32. https://doi.org/10.3390/ijms21249373
MLA:
Prasad, Binod, et al. "Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro." International Journal of Molecular Sciences 21.24 (2020): 1-32.
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