Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors
Wagner S, de Moura Gatti F, Silva DG, Ortiz Zacarias NV, Zweemer AJ, Hermann S, de Maria M, Koch M, Weiss C, Schepmann D, Heitman LH, Tschammer N, Kopka K, Junker A (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Abstract
Herein we report the design and synthesis of a series of highly selective CCR2 antagonists as 18F-labeled PET tracers. The derivatives were evaluated extensively for their off-target profile at 48 different targets. The most potent and selective candidate was applied in vivo in a biodistribution study, demonstrating a promising profile for further preclinical development. This compound represents the first potential nonpeptidic PET tracer for the imaging of CCR2 receptors.
Authors with CRIS profile
Monica de Maria
Lehrstuhl für Entwicklungsbiologie (Ebio)
Nuska Tschammer
Lehrstuhl für Pharmazeutische Chemie
Involved external institutions
Universitätsklinikum Münster
Germany (DE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
Leiden University
Netherlands (NL)
Bayer AG
Germany (DE)
Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
Germany (DE)
Germany (DE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
Leiden University
Netherlands (NL)
Bayer AG
Germany (DE)
Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
Germany (DE)
How to cite
APA:
Wagner, S., de Moura Gatti, F., Silva, D.G., Ortiz Zacarias, N.V., Zweemer, A.J., Hermann, S.,... Junker, A. (2020). Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors. ChemMedChem. https://dx.doi.org/10.1002/cmdc.202000728
MLA:
Wagner, Stefan, et al. "Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors." ChemMedChem (2020).
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