The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation

Krönke G, Uderhardt S, Katzenbeisser J, Schett G (2009)

Publication Type: Journal article

Publication year: 2009

Journal

Autoimmunity Informa Healthcare

Book Volume: 42

Pages Range: 383-385

Journal Issue: 4

DOI: 10.1080/08916930902832488

Abstract

Although 12/15-lipoxygenase (12/15-LO) has been implicated as negative regulator of systemic bone mass in mice and humans, the underlying mechanisms remain elusive. Here, we show that 12/15-LO is a positive regulator of osteoclast (OC) development. Enzymatic inhibition as well as genetic ablation of 12/15-LO significantly impaired osteoclastogenesis. Conversely, addition of the 12/15-LO-derived eicosanoids 12- and 15-HETE augmented differentiation of precursors into fully matured OCs. Together these data point towards a crucial role of 12/15-LO in the regulation of OC development. Therefore, 12/15-LO and its human homologue 15-LO may display novel targets for the treatment of diseases such as osteoporosis and rheumatoid arthritis. © 2009 Informa UK Ltd All rights reserved.

Authors with CRIS profile

Gerhard Krönke Department of Medicine 3 – Rheumatology and Immunology Stefan Uderhardt Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III

How to cite

APA:

Krönke, G., Uderhardt, S., Katzenbeisser, J., & Schett, G. (2009). The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity, 42(4), 383-385. https://doi.org/10.1080/08916930902832488

MLA:

Krönke, Gerhard, et al. "The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation." Autoimmunity 42.4 (2009): 383-385.

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