Targeted Natural Killer Cell-Based Adoptive Immunotherapy for the Treatment of Patients with NSCLC after Radiochemotherapy: A Randomized Phase II Clinical Trial

Multhoff G, Seier S, Stangl S, Sievert W, Shevtsov M, Werner C, Pockley AG, Blankenstein C, Hildebrandt M, Offner R, Ahrens N, Kokowski K, Hautmann M, Roedel C, Fietkau R, Lubgan D, Huber R, Hautmann H, Duell T, Molls M, Specht H, Haller B, Devecka M, Sauter A, Combs SE (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Clinical Cancer Research American Association for Cancer Research

Book Volume: 26

Pages Range: 5368-5379

Journal Issue: 20

DOI: 10.1158/1078-0432.CCR-20-1141

Abstract

Purpose: Non-small cell lung cancer (NSCLC) is a fatal disease with poor prognosis. Amembrane-bound form of Hsp70 (mHsp70) which is selectively expressed on high-risk tumors serves as a target for mHsp70-targeting natural killer (NK) cells. Patients with advanced mHsp70-positive NSCLC may therefore benefit from a therapeutic intervention involving mHsp70-targeting NK cells. The randomized phase II clinical trial (EudraCT2008-002130-30) explores tolerability and efficacy of ex vivo-activated NK cells in patients with NSCLC after radiochemotherapy (RCT).

Authors with CRIS profile

Rainer Fietkau Lehrstuhl für Strahlentherapie Dorota Lubgan Department of Radiation Oncology

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Nottingham Trent University GB United Kingdom (GB) Universitätsklinikum Regensburg DE Germany (DE) Städtisches Klinikum München DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE)

How to cite

APA:

Multhoff, G., Seier, S., Stangl, S., Sievert, W., Shevtsov, M., Werner, C.,... Combs, S.E. (2020). Targeted Natural Killer Cell-Based Adoptive Immunotherapy for the Treatment of Patients with NSCLC after Radiochemotherapy: A Randomized Phase II Clinical Trial. Clinical Cancer Research, 26(20), 5368-5379. https://doi.org/10.1158/1078-0432.CCR-20-1141

MLA:

Multhoff, Gabriele, et al. "Targeted Natural Killer Cell-Based Adoptive Immunotherapy for the Treatment of Patients with NSCLC after Radiochemotherapy: A Randomized Phase II Clinical Trial." Clinical Cancer Research 26.20 (2020): 5368-5379.

BibTeX: Download