Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer

Mueller SK, Mantsopoulos K, Semrau S, Agaimy A, Eckstein M, Traxdorf M, Gostian AO, Goncalves M, Sievert M, Haderlein M, Grundtner P, Hecht M, Koch M, Fietkau R, Iro H, Scherl C (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Acta Oto-Laryngologica Informa Healthcare

DOI: 10.1080/00016489.2020.1831697

Abstract

Background: Human papillomavirus (HPV)+ and HPV– oropharyngeal squamous cell carcinomas (OPSCC) are separate tumor entities. Aims/Objectives: The aim of this study was to examine if the p16 status influences the need and outcome of a salvage neck dissection (SND) after primary radiochemotherapy (pRCT). Material and methods: Retrospective study of 164 patients (n = 108 p16–, n = 56 p16+) who underwent pRCT for OPSCC between 2009 and 2016. HPV status was defined via p16 immunohistochemical staining. Clinical nodal status was assessed using ultrasound and computed tomography of the neck with contrast. Results: Of the 56 p16+ patients, 17 (30.4%) patients were given an indication for a SND after pRCT with 4 (23.5%) patients showing persistent malignant nodes. Of the 108 p16– patients, 24 (22.2%) patients underwent a SND with 8 (33.3%) patients showing persistent malignant nodes. There was no significant association of the p16 status and neither the indication for SND (p(Chi²(two-sided)-Test) = 0.25, ϕ = 0.34) nor the occurrence of positive nodes (p(Chi²(two-sided)-Test) = 0.74, ϕ = 0.50). The probability for persistence of the ypN + nodal status independent of HPV-status was 29.2%(12/41). Conclusions and significance: There was neither a significant association between the p16 status and the indication for a SND nor for persistent malignant nodal disease after pRCT.

Authors with CRIS profile

Sarina Müller-Hübner Department of Otorhinolaryngology – Head and Neck Surgery Konstantinos Mantsopoulos Department of Otorhinolaryngology – Head and Neck Surgery Sabine Semrau Medizinische Fakultät Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Markus Eckstein Institute of Pathology Maximilian Traxdorf Medizinische Fakultät Miguel Goncalves Department of Otorhinolaryngology – Head and Neck Surgery Matti Sievert Department of Otorhinolaryngology – Head and Neck Surgery Marlen Haderlein Department of Radiation Oncology Markus Hecht Department of Radiation Oncology Rainer Fietkau Lehrstuhl für Strahlentherapie Heinrich Iro Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde

How to cite

APA:

Mueller, S.K., Mantsopoulos, K., Semrau, S., Agaimy, A., Eckstein, M., Traxdorf, M.,... Scherl, C. (2020). Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer. Acta Oto-Laryngologica. https://doi.org/10.1080/00016489.2020.1831697

MLA:

Mueller, Sarina K., et al. "Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer." Acta Oto-Laryngologica (2020).

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