Coxiella burnetii-infected NK cells release infectious bacteria by degranulation
Matthiesen S, Zaeck L, Franzke K, Jahnke R, Fricke C, Mauermeir M, Finke S, Lührmann A, Knittler MR (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 88
Article Number: e00172
Journal Issue: 11
DOI: 10.1128/IAI.00172-20
Abstract
Natural killer (NK) cells are critically involved in the early immune response against various intracellular pathogens, including Coxiella burnetii and Chlamydia psittaci. Chlamydia-infected NK cells functionally mature, induce cellular immunity, and protect themselves by killing the bacteria in secreted granules. Here, we report that infected NK cells do not allow intracellular multiday growth of Coxiella, as is usually observed in other host cell types. C. burnetii-infected NK cells display maturation and gamma interferon (IFN-) secretion, as well as the release of Coxiella-containing lytic granules. Thus, NK cells possess a potent program to restrain and expel different types of invading bacteria via degranulation. Strikingly, though, in contrast to Chlamydia, expulsed Coxiella organisms largely retain their infectivity and, hence, escape the cell-autonomous self-defense mechanism in NK cells.
Authors with CRIS profile
Michael Mauermeir
Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene
Anja Lührmann
Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene
Involved external institutions
Germany (DE)How to cite
APA:
Matthiesen, S., Zaeck, L., Franzke, K., Jahnke, R., Fricke, C., Mauermeir, M.,... Knittler, M.R. (2020). Coxiella burnetii-infected NK cells release infectious bacteria by degranulation. Infection and Immunity, 88(11). https://doi.org/10.1128/IAI.00172-20
MLA:
Matthiesen, Svea, et al. "Coxiella burnetii-infected NK cells release infectious bacteria by degranulation." Infection and Immunity 88.11 (2020).
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