Dietary short-term fiber interventions in arthritis patients increase systemic scfa levels and regulate inflammation

Dürholz K, Hofmann J, Iljazovic A, Häger J, Lucas S, Sarter K, Strowig T, Bang H, Rech J, Schett G, Zaiss M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Nutrients MDPI

Book Volume: 12

Pages Range: 1-11

Article Number: 3207

Journal Issue: 10

DOI: 10.3390/nu12103207

Abstract

Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro-and anti-inflammatory mediators in the joints, thereby favoring chronic inflammation and joint damage. Here, we investigate if short-term high-fiber dietary intervention shifts this towards anti-inflammatory mediators. Healthy controls (n = 10) and RA patients (n = 29) under routine care received daily high-fiber bars for 15 or 30 days, respectively. Stool and sera were analyzed for pro-and anti-inflammatory mediators. A high-fiber dietary intervention resulted in increased anti-inflammatory short-chain fatty acids (SCFA), decreased proarthritic cytokine concentrations, along with a durable shift in the Firmicutes-to-Bacteroidetes ratio. Together, these results further strengthen high-fiber dietary interventions as a practical approach complementing existing pharmacological therapies.

Authors with CRIS profile

Kerstin Dürholz Department of Medicine 3 – Rheumatology and Immunology Jörg Hofmann Lehrstuhl für Biochemie Sébastien Lucas Department of Medicine 3 – Rheumatology and Immunology Kerstin Sarter-Zaiss Department of Medicine 3 – Rheumatology and Immunology Hans Jürgen Rech Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III Mario Zaiss Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Helmholtz-Zentrum für Infektionsforschung (HZI) DE Germany (DE) Melio.Care GmbH DE Germany (DE)

How to cite

APA:

Dürholz, K., Hofmann, J., Iljazovic, A., Häger, J., Lucas, S., Sarter, K.,... Zaiss, M. (2020). Dietary short-term fiber interventions in arthritis patients increase systemic scfa levels and regulate inflammation. Nutrients, 12(10), 1-11. https://doi.org/10.3390/nu12103207

MLA:

Dürholz, Kerstin, et al. "Dietary short-term fiber interventions in arthritis patients increase systemic scfa levels and regulate inflammation." Nutrients 12.10 (2020): 1-11.

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