Magnetite-arginine nanoparticles as a multifunctional biomedical tool
Reichel VE, Matuszak J, Bente K, Heil T, Kraupner A, Dutz S, Cicha I, Faivre D (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 10
Pages Range: 1-14
Article Number: 2014
Journal Issue: 10
DOI: 10.3390/nano10102014
Abstract
Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovist®), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovist®). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridex®, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity.
Authors with CRIS profile
Jasmin Matuszak
Department of Otorhinolaryngology – Head and Neck Surgery
Iwona Cicha
Medizinische Fakultät
Involved external institutions
Max-Planck-Institut für Kolloid- und Grenzflächenforschung / Max Planck Institute of Colloids and Interfaces
Germany (DE)
nanoPET Pharma GmbH
Germany (DE)
Technische Universität Ilmenau
Germany (DE)
Germany (DE)
nanoPET Pharma GmbH
Germany (DE)
Technische Universität Ilmenau
Germany (DE)
How to cite
APA:
Reichel, V.E., Matuszak, J., Bente, K., Heil, T., Kraupner, A., Dutz, S.,... Faivre, D. (2020). Magnetite-arginine nanoparticles as a multifunctional biomedical tool. Nanomaterials, 10(10), 1-14. https://dx.doi.org/10.3390/nano10102014
MLA:
Reichel, Victoria E., et al. "Magnetite-arginine nanoparticles as a multifunctional biomedical tool." Nanomaterials 10.10 (2020): 1-14.
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