SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene

Ziegler K, Steininger P, Ziegler R, Steinmann J, Korn K, Enßer A (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Eurosurveillance Institut de Veille Sanitaire

Book Volume: 25

Article Number: 2001650

Journal Issue: 39

DOI: 10.2807/1560-7917.ES.2020.25.39.2001650

Abstract

We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent essential regions of a pathogen for reliable detection.

Authors with CRIS profile

Philipp Steininger Institute of Clinical and Molecular Virology Klaus Korn Institute of Clinical and Molecular Virology Armin Enßer Medizinische Fakultät

Involved external institutions

Paracelsus Medizinische Privatuniversität, Nürnberg

Germany (DE)

How to cite

APA:

Ziegler, K., Steininger, P., Ziegler, R., Steinmann, J., Korn, K., & Enßer, A. (2020). SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene. Eurosurveillance, 25(39). https://doi.org/10.2807/1560-7917.ES.2020.25.39.2001650

MLA:

Ziegler, Katharina, et al. "SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene." Eurosurveillance 25.39 (2020).

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