Lymphatic and vascular invasion in oral squamous cell carcinoma: Implications for recurrence and survival in a population-based cohort study
Spoerl S, Gerken M, Fischer R, Mamilos A, Spoerl S, Wolf S, Pohl F, Klingelhöffer C, Ettl T, Reichert TE, Spanier G (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 111
Article Number: 105009
DOI: 10.1016/j.oraloncology.2020.105009
Abstract
Objective: Numerous studies analyzed lymphovascular invasion (LVI) in various malignant diseases, however, little is known about the role of lymphatic invasion (LI) as well as vascular invasion (VI) in oral squamous cell carcinoma (OSCC). The aim of this study is to illuminate the role of LI and VI in a population-based cohort study. Methods: We retrospectively analyzed 745 primarily resected OSCC patients in Eastern Bavaria for histopathologically verified LI and VI. Overall survival (OS) and recurrence-free survival (RFS) were calculated, whereas analysis was performed by uni- and multivariate statistics. Mean follow-up time was 7.4 years. Results: LI was found in 115 patients (15.4%), VI was diagnosed in 23 cases (3.1%). LI correlated significantly with distinct anatomical sites (p = 0.004), increasing pT-classification (p < 0.001), lymph node involvement (p < 0.001), higher grading (p < 0.001), advanced UICC-stages (p < 0.001) and adjuvant therapies (p < 0.001). Similar results were found for VI. Survival analysis resulted in a significantly decreased five-year OS and RFS in patients with diagnosed LI (OS: 41.1%, RFS: 38.3%) in contrast to LI-negative cases (OS: 66.8%, RFS: 59.7.7%, p < 0.001). Analogous outcomes were seen for patients with VI. Additionally, LI was identified as a predictive parameter, indicating individual patients’ response to adjuvant therapies. Conclusion: This population-based cohort study underlines the unfavorable aspect of LI and VI on outcome in OSCC. Including LI and VI in existing staging systems could help to stratify patients’ risk for adverse outcome and consecutively determine adjuvant treatment in malignant disease.
Involved external institutions
Universitätsklinikum Regensburg
Germany (DE)
Klinikum St. Elisabeth Straubing GmbH
Germany (DE)
Universität Regensburg
Germany (DE)
Germany (DE)
Klinikum St. Elisabeth Straubing GmbH
Germany (DE)
Universität Regensburg
Germany (DE)
How to cite
APA:
Spoerl, S., Gerken, M., Fischer, R., Mamilos, A., Spoerl, S., Wolf, S.,... Spanier, G. (2020). Lymphatic and vascular invasion in oral squamous cell carcinoma: Implications for recurrence and survival in a population-based cohort study. Oral Oncology, 111. https://doi.org/10.1016/j.oraloncology.2020.105009
MLA:
Spoerl, Steffen, et al. "Lymphatic and vascular invasion in oral squamous cell carcinoma: Implications for recurrence and survival in a population-based cohort study." Oral Oncology 111 (2020).
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