Calorimetric approach to assess the apatite-forming capacity of bioactive glasses

Zine Elabidine M, Cherbib MA, Khattech I, Bechrifa A, Schuhladen K, Brauer DS, Boccaccini AR (2020)

Publication Type: Journal article

Publication year: 2020


Book Volume: 550

Article Number: 120290

DOI: 10.1016/j.jnoncrysol.2020.120290


This paper investigates a new microcalorimetric approach to assess the capacity of bioactive glasses, to form hydroxyapatite during immersion in physiological fluids. Three silicate glasses were selected namely 45S5 (46.1SiO2-2.6P2O5-26.9CaO-24.4Na2O; mol%), F0 (46.1SiO2-2.6P2O5-37.6CaO-6.8Na2O-6.8K2O; mol%), and F3 (44.8SiO2-2.5P2O5-36.5CaO-6.6Na2O-6.6K2O-3.0CaF2; mol%), synthesized by a melt-quench route and studied initially using electron microscopy. The hydroxyapatite formation of samples immersed in simulated body fluid (SBF) was monitored using X-ray diffraction and Infrared spectroscopy. The microcalorimetric investigations were conducted by observing, over seven days, the thermochemical behavior of glasses in SBF at 37°C and by measuring the heat of acidic dissolution of treated and untreated samples in SBF. The results showed that the samples with the higher capacity to form apatites also present the higher heat variation from day-to-day, with 45S5 presenting the highest heat difference recorded in both experiments. These analyses led to the quantification of the calcium phosphate formed for each bioactive glass composition.

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Zine Elabidine, M., Cherbib, M.A., Khattech, I., Bechrifa, A., Schuhladen, K., Brauer, D.S., & Boccaccini, A.R. (2020). Calorimetric approach to assess the apatite-forming capacity of bioactive glasses. Journal of Non-Crystalline Solids, 550.


Zine Elabidine, Mohamed, et al. "Calorimetric approach to assess the apatite-forming capacity of bioactive glasses." Journal of Non-Crystalline Solids 550 (2020).

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