Layered titanates with fibrous nanotopographic features as reservoir for bioactive ions to enhance osteogenesis
Song X, Tang W, Gregurec D, Yate L, Moya SE, Wang G (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 436
Pages Range: 653-661
DOI: 10.1016/j.apsusc.2017.12.027
Abstract
In this study, an osteogenic environment was constructed on Ti alloy implants by in-situ formation of nanosized fibrous titanate, Na 2 Ti 6 O 13 , loaded with bioactive ions, i.e. Sr, Mg and Zn, to enhance surface bioactivity. The bioactive ions were loaded by ion exchange with sodium located at inter-layer positions between the TiO 6 slabs, and their release was not associated with the degradation of the structural unit of the titanate. In-vitro cell culture experiments using MC3T3-E1 cells proved that both bioactive ions and nanotopographic features are critical in promoting osteogenic differentiation of the cells. It was found that the osteogenic functions of the titanate can be modulated by the type and amount of ions incorporated. This study points out that nanosized fibrous titanate formed on the Ti alloy can be a promising reservoir for bioactive ions. The major advantage of this approach over other alternatives for bioactive ion delivery using degradable bioceramic coatings is its capacity of maintaining the structural integrity of the coating and thus avoiding structural deterioration and potential mechanical failure.
Authors with CRIS profile
Involved external institutions
CIC biomaGUNE (Centro de Investigación Cooperativa en Biomateriales)
Spain (ES)
Chinese Academy of Sciences (CAS) / 中国科学院
China (CN)
Spain (ES)
Chinese Academy of Sciences (CAS) / 中国科学院
China (CN)
How to cite
APA:
Song, X., Tang, W., Gregurec, D., Yate, L., Moya, S.E., & Wang, G. (2018). Layered titanates with fibrous nanotopographic features as reservoir for bioactive ions to enhance osteogenesis. Applied Surface Science, 436, 653-661. https://doi.org/10.1016/j.apsusc.2017.12.027
MLA:
Song, Xiaoxia, et al. "Layered titanates with fibrous nanotopographic features as reservoir for bioactive ions to enhance osteogenesis." Applied Surface Science 436 (2018): 653-661.
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