Gregurec D, Politakos N, Yate L, Moya SE (2019)
Publication Type: Journal article
Publication year: 2019
Book Volume: 4
Pages Range: 421-430
Journal Issue: 2
DOI: 10.1039/c8me00089a
Polyacrylic acid (PAA) brushes synthesized by reversible addition fragment chain transfer (RAFT) polymerization on titania (TiO2) surfaces were applied for the surface confinement and slow delivery of strontium (Sr2+) ions during the osseointegration process on TiO2 surfaces. Sr2+ is an essential element in the bone remodeling cycle and has large potential for application in therapies for bone-related diseases and bone replacement. Sr2+ complexation to the carboxylate groups of PAA was demonstrated by XPS while Sr2+ release in media was studied by ICP-MS. The Sr2+ concentration was varied by preparing PAA brushes at two grafting densities. At the higher grafting density, the brushes offer more carboxyl groups for Sr2+ binding. The architecture of the brushes and the amount of Sr2+ is controlled by the density of polymer chains. The morphology and brush thickness were characterized by AFM and ellipsometry. The significant effects of PAA brush coated TiO2 complexing Sr2+ on osteoblast cells is shown. The use of PAA brushes for Sr2+ confinement restricts Sr2+ activity to the cells in direct contact with the TiO2 surface. Initial adhesion of osteoblast cells is superior on coatings with brushes compared to bare TiO2. Moreover, a rather rapid cell tissue formation is observed for the cells cultured on the brushes with higher Sr2+ content. Enhanced biocompatibility and osseoactivity is confirmed by an increased alkaline phosphatase activity.
APA:
Gregurec, D., Politakos, N., Yate, L., & Moya, S.E. (2019). Strontium confinement in polyacrylic acid brushes: A soft nanoarchitectonics approach for the design of titania coatings with enhanced osseointegration. Molecular Systems Design & Engineering, 4(2), 421-430. https://doi.org/10.1039/c8me00089a
MLA:
Gregurec, Danijela, et al. "Strontium confinement in polyacrylic acid brushes: A soft nanoarchitectonics approach for the design of titania coatings with enhanced osseointegration." Molecular Systems Design & Engineering 4.2 (2019): 421-430.
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