Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling

Moon J, Christiansen MG, Rao S, Marcus C, Bono DC, Rosenfeld D, Gregurec D, Varnavides G, Chiang PH, Park S, Anikeeva P (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Advanced Functional Materials Wiley-VCH Verlag

Book Volume: 30

Article Number: 2000577

Journal Issue: 36

DOI: 10.1002/adfm.202000577

Abstract

Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make use of heat dissipation by ferrite nanoparticles under alternating magnetic fields, with these fields acting as an externally administered stimulus that is either present or absent, toggling heat dissipation on and off. Here, an extension of this concept, magnetothermal multiplexing is demonstrated, in which exposure to alternating magnetic fields of differing amplitude and frequency can result in selective and independent heating of magnetic nanoparticle ensembles. The differing magnetic coercivity of these particles, empirically characterized by a custom high amplitude alternating current magnetometer, informs the systematic selection of a multiplexed material system. This work culminates in a demonstration of magnetothermal multiplexing for selective remote control of cellular signaling in vitro.

Authors with CRIS profile

Danijela Gregurec

Involved external institutions

Massachusetts Institute of Technology (MIT) US United States (USA) (US) École Polytechnique Fédérale de Lausanne (EPFL) CH Switzerland (CH) CIC biomaGUNE (Centro de Investigación Cooperativa en Biomateriales) ES Spain (ES)

How to cite

APA:

Moon, J., Christiansen, M.G., Rao, S., Marcus, C., Bono, D.C., Rosenfeld, D.,... Anikeeva, P. (2020). Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling. Advanced Functional Materials, 30(36). https://doi.org/10.1002/adfm.202000577

MLA:

Moon, Junsang, et al. "Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling." Advanced Functional Materials 30.36 (2020).

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