Bmp signaling exerts opposite effects on cardiac differentiation
De Pater E, Ciampricotti M, Priller F, Veerkamp J, Strate I, Smith K, Lagendijk AK, Schilling TF, Herzog W, Abdelilah-Seyfried S, Hammerschmidt M, Bakkers J (2012)
Publication Type: Journal article
Publication year: 2012
Journal
Book Volume: 110
Pages Range: 578-587
Journal Issue: 4
DOI: 10.1161/CIRCRESAHA.111.261172
Abstract
RATIONALE: The importance for Bmp signaling during embryonic stem cell differentiation into myocardial cells has been recognized. The question when and where Bmp signaling in vivo regulates myocardial differentiation has remained largely unanswered. OBJECTIVE: To identify when and where Bmp signaling regulates cardiogenic differentiation. METHODS AND RESULTS: Here we have observed that in zebrafish embryos, Bmp signaling is active in cardiac progenitor cells prior to their differentiation into cardiomyocytes. Bmp signaling is continuously required during somitogenesis within the anterior lateral plate mesoderm to induce myocardial differentiation. Surprisingly, Bmp signaling is actively repressed in differentiating myocardial cells. We identified the inhibitory Smad6a, which is expressed in the cardiac tissue, to be required to inhibit Bmp signaling and thereby promote expansion of the ventricular myocardium. CONCLUSION: Bmp signaling exerts opposing effects on myocardial differentiation in the embryo by promoting as well as inhibiting cardiac growth. © 2012 American Heart Association, Inc.
Authors with CRIS profile
Involved external institutions
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Germany (DE)
Universität zu Köln
Germany (DE)
Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine
Germany (DE)
University of California Irvine
United States (USA) (US)
Netherlands (NL)
Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Germany (DE)
Universität zu Köln
Germany (DE)
Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine
Germany (DE)
University of California Irvine
United States (USA) (US)
How to cite
APA:
De Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K.,... Bakkers, J. (2012). Bmp signaling exerts opposite effects on cardiac differentiation. Circulation Research, 110(4), 578-587. https://doi.org/10.1161/CIRCRESAHA.111.261172
MLA:
De Pater, Emma, et al. "Bmp signaling exerts opposite effects on cardiac differentiation." Circulation Research 110.4 (2012): 578-587.
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