Lymphatic vessels arise from specialized angioblasts within a venous niche

Nicenboim J, Malkinson G, Lupo T, Asaf L, Sela Y, Mayseless O, Gibbs-Bar L, Senderovich N, Hashimshony T, Shin M, Jerafi-Vider A, Avraham-Davidi I, Krupalnik V, Hofi R, Almog G, Astin JW, Golani O, Ben-Dor S, Crosier PS, Herzog W, Lawson ND, Hanna JH, Yanai I, Yaniv K (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Nature Nature Research

Book Volume: 522

Pages Range: 56-61

Journal Issue: 7554

DOI: 10.1038/nature14425

Abstract

How cells acquire their fate is a fundamental question in developmental and regenerative biology. Multipotent progenitors undergo cell-fate restriction in response to cues from the microenvironment, the nature of which is poorly understood. In the case of the lymphatic system, venous cells from the cardinal vein are thought to generate lymphatic vessels through trans-differentiation. Here we show that in zebrafish, lymphatic progenitors arise from a previously uncharacterized niche of specialized angioblasts within the cardinal vein, which also generates arterial and venous fates. We further identify Wnt5b as a novel lymphatic inductive signal and show that it also promotes the 'angioblast-to-lymphatic' transition in human embryonic stem cells, suggesting that this process is evolutionarily conserved. Our results uncover a novel mechanism of lymphatic specification, and provide the first characterization of the lymphatic inductive niche. More broadly, our findings highlight the cardinal vein as a heterogeneous structure, analogous to the haematopoietic niche in the aortic floor.

Authors with CRIS profile

Wiebke Herzog

Involved external institutions

Technion - Israel Institute of Technology IL Israel (IL) University of Auckland NZ New Zealand (NZ) Weizmann Institute of Science IL Israel (IL) Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE) University of Massachusetts Medical School US United States (USA) (US)

How to cite

APA:

Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O.,... Yaniv, K. (2015). Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature, 522(7554), 56-61. https://doi.org/10.1038/nature14425

MLA:

Nicenboim, J., et al. "Lymphatic vessels arise from specialized angioblasts within a venous niche." Nature 522.7554 (2015): 56-61.

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