Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions

Bornhorst D, Xia P, Nakajima H, Dingare C, Herzog W, Lecaudey V, Mochizuki N, Heisenberg CP, Yelon D, Abdelilah-Seyfried S (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Nature Communications Nature Publishing Group: Nature Communications

Book Volume: 10

Article Number: 4113

Journal Issue: 1

DOI: 10.1038/s41467-019-12068-x

Abstract

Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissue is relaxed.

Authors with CRIS profile

Wiebke Herzog

Involved external institutions

IST Austria AT Austria (AT) Universität Potsdam DE Germany (DE) National Cerebral and Cardiovascular Center JP Japan (JP) Goethe-Universität Frankfurt am Main DE Germany (DE) Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine DE Germany (DE) University of California, San Diego US United States (USA) (US)

How to cite

APA:

Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V.,... Abdelilah-Seyfried, S. (2019). Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature Communications, 10(1). https://dx.doi.org/10.1038/s41467-019-12068-x

MLA:

Bornhorst, Dorothee, et al. "Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions." Nature Communications 10.1 (2019).

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