Control of immune-mediated pathology via the aryl hydrocarbon receptor
Wheeler MA, Rothhammer V, Quintana FJ (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 292
Pages Range: 12383-12389
Journal Issue: 30
Abstract
Genetic and environmental factors contribute to the development of immune-mediated diseases. Although numerous genetic factors contributing to autoimmunity have been identified in recent years, our knowledge on environmental factors contributing to the pathogenesis of autoimmune diseases and the mechanisms involved is still limited. In this context, the diet, microbiome, geographical location, as well as environmental pollutants have been shown to modulate autoimmune disease development. These environmental factors interact with cellular components of the immune system in distinct and defined ways and can influence immune responses at the transcriptional and protein level. Moreover, endogenous metabolites generated from basic cellular processes such as glycolysis and oxidative phosphorylation also contribute to the shaping of the immune response. In this minireview, we highlight recent progress in our understanding of the modulation of the immune response by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor whose activity is regulated by small molecules provided by diet, commensal flora, environmental pollutants, and metabolism. We focus on the role of AhR in integrating signals from the diet and the intestinal flora to modulate ongoing inflammation in the central nervous system, and we also discuss the potential therapeutic value of AhR agonists for multiple sclerosis and other autoimmune diseases.
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APA:
Wheeler, M.A., Rothhammer, V., & Quintana, F.J. (2017). Control of immune-mediated pathology via the aryl hydrocarbon receptor. Journal of Biological Chemistry, 292(30), 12383-12389. https://doi.org/10.1074/jbc.R116.767723
MLA:
Wheeler, Michael A., Veit Rothhammer, and Francisco J. Quintana. "Control of immune-mediated pathology via the aryl hydrocarbon receptor." Journal of Biological Chemistry 292.30 (2017): 12383-12389.
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