Impact of microvascular disease on cardiovascular outcomes in type 2 diabetes: Results from the LEADER and SUSTAIN 6 clinical trials

Verma S, Bain SC, Honoré JB, Mann J, A. Nauck M, E. Pratley R, Rasmussen S, Sejersten Ripa M, Zinman B, Buse JB (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Diabetes Obesity & Metabolism Wiley-Blackwell

DOI: 10.1111/dom.14140

Abstract

The randomized, double-blind, cardiovascular outcomes trials LEADER (NCT01179048) and SUSTAIN 6 (NCT01720446) showed cardiovascular risk reduction in patients with type 2 diabetes treated with liraglutide and semaglutide, respectively, compared with placebo. This post hoc analysis examined the impact of microvascular disease at baseline on cardiovascular outcomes in these trials, and the efficacy of liraglutide (1.8 mg) and once-weekly semaglutide (0.5-1.0 mg) in patients with and without microvascular disease. In total, 9340 patients from LEADER and 3297 patients from SUSTAIN 6 were included in this analysis; of these, 5761 and 2356 had a history of microvascular disease at baseline and 3835 and 1640 had a history of both microvascular and macrovascular disease, respectively. Patients with microvascular disease were shown to have an increased risk of major adverse cardiovascular events compared with patients without microvascular disease (hazard ratio [95% confidence interval] in LEADER: 1.15 [1.03; 1.29], P =.0136; SUSTAIN 6: 1.56 [1.14; 2.17], P =.0064). Liraglutide and semaglutide consistently reduced cardiovascular risk in patients with and without microvascular disease.

Involved external institutions

St. Michael's Hospital CA Canada (CA) University of North Carolina at Chapel Hill US United States (USA) (US) AdventHealth US United States (USA) (US) Katholisches Klinikum Bochum (St. Josef- und St. Elisabeth-Hospital gGmbH) DE Germany (DE) Novo Nordisk A/S DK Denmark (DK) Swansea University GB United Kingdom (GB) University of Toronto CA Canada (CA)

How to cite

APA:

Verma, S., Bain, S.C., Honoré, J.B., Mann, J., A. Nauck, M., E. Pratley, R.,... Buse, J.B. (2020). Impact of microvascular disease on cardiovascular outcomes in type 2 diabetes: Results from the LEADER and SUSTAIN 6 clinical trials. Diabetes Obesity & Metabolism. https://doi.org/10.1111/dom.14140

MLA:

Verma, Subodh, et al. "Impact of microvascular disease on cardiovascular outcomes in type 2 diabetes: Results from the LEADER and SUSTAIN 6 clinical trials." Diabetes Obesity & Metabolism (2020).

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