Operationsindikationen bei neuroendokrinen Neoplasien des Pankreas

Bösch F, Belyaev O, Brunner M, Müller-Debus CF, Grützmann R, Keck T, Uhl W, Witzigmann H, Werner J (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Zentralblatt für Chirurgie Georg Thieme Verlag

DOI: 10.1055/a-1168-7103

Abstract

Neuroendocrine neoplasms of the pancreas (pNEN) have an increasing incidence and prevalence. Thus, this entity is of increasing clinical significance. Patients with pNEN become clinically apparent due to different and unspecific symptoms. Some tumours secrete hormones and peptides and become clinically symptomatic. In general, these tumours can metastasise early and even small tumours lead to distant metastases. Nonetheless, primary tumour size and grading are important prognostic factors. On the basis of a systematic literature research and the formulation of key issues according to the PICO system, therapeutic concepts were established. These concepts were evaluated with a Delphi process among the members of the pancreas research group and the indications for surgery group of the German Society of General and Visceral Surgery. Thus this article gives an overview of the surgical treatment modalities and indications for the treatment of pNEN. Surgery is still the gold standard in treatment and the only potential chance of cure. Surgery is indicated for sporadic as well as hereditary pNEN > 2 cm independent of the functional activity. A so called wait and see strategy might be indicated in smaller pNEN; however, there is little evidence for this approach. In this respect, pNEN of 1-2 cm represent a surgical indication. The treatment of hereditary pNEN is challenging and should be interdisciplinary. Even in the case of distant metastases, a curative approach might be feasible and multimodal treatment is indicated.

Authors with CRIS profile

Maximilian Brunner Lehrstuhl für Allgemein- und Viszeralchirurgie Robert Grützmann Lehrstuhl für Allgemein- und Viszeralchirurgie

Involved external institutions

Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Katholisches Klinikum Bochum (St. Josef- und St. Elisabeth-Hospital gGmbH) DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Krankenhaus Dresden-Friedrichstadt, Städtisches Klinikum DE Germany (DE)

How to cite

APA:

Bösch, F., Belyaev, O., Brunner, M., Müller-Debus, C.F., Grützmann, R., Keck, T.,... Werner, J. (2020). Operationsindikationen bei neuroendokrinen Neoplasien des Pankreas. Zentralblatt für Chirurgie. https://doi.org/10.1055/a-1168-7103

MLA:

Bösch, Florian, et al. "Operationsindikationen bei neuroendokrinen Neoplasien des Pankreas." Zentralblatt für Chirurgie (2020).

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