Menthacarin attenuates experimental colitis
Alliger K, Khalil M, König B, Weisenburger S, Koch E, Engel M (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 77
Article Number: 153212
DOI: 10.1016/j.phymed.2020.153212
Abstract
Background: Peppermint oil and caraway oil are established remedies in gastroenterological medicine because of their spasmolytic/analgesic effects. Purpose: We investigated whether Menthacarin, a combination of both oils, exerted anti-inflammatory effects in a dextran sodium sulphate (DSS, 2%) murine model of colitis. Study Design and Methods: C57BL/6 mice were orally administered Menthacarin in doses of 10, 30, 60, and 120 µg/g body weight (BW), and control mice received 0.2% agar, 10 µl/g BW, during 8 days of DSS-induced colitis. Colitis was monitored by BW measurements and colonoscopies. Colons of euthanised mice were excised for histological staining and ELISA measurements of the cytokines TNFα, IL-6, IL-10, IL-1β, and TGF-β. Results: Menthacarin-treated mice compared to controls showed improved macroscopical and microscopical parameters and lower BW loss during the course of colitis. Menthacarin changed the colonic cytokine profile towards a regulatory/anti-inflammatory phenotype. Conclusion: Menthacarin attenuates experimental colitis and may be a promising add-on therapy for the treatment of IBD.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Alliger, K., Khalil, M., König, B., Weisenburger, S., Koch, E., & Engel, M. (2020). Menthacarin attenuates experimental colitis. Phytomedicine, 77. https://dx.doi.org/10.1016/j.phymed.2020.153212
MLA:
Alliger, Korina, et al. "Menthacarin attenuates experimental colitis." Phytomedicine 77 (2020).
BibTeX: Download