Effect of exercise training on bone mineral density in post-menopausal women: A systematic review and meta-analysis of intervention studies

Shojaa M, von Stengel S, Schöne D, Kohl M, Barone G, Bragonzoni L, Dallolio L, Marini S, Murphy MH, Stephenson A, Mänty M, Julin M, Risto T, Kemmler W (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Book Volume: 11

Article Number: 652

DOI: 10.3389/fphys.2020.00652

Abstract

Osteoporosis is a major health problem in post-menopausal women (PMW). Exercise training is considered a cost-effective strategy to prevent osteoporosis in middle aged-older people. The purpose of this study is to summarize the effect of exercise on BMD among PMW. A comprehensive search of electronic databases was conducted through PubMed, Scopus, Web of Science, Cochrane, Science Direct, Eric, ProQuest, and Primo. BMD changes (standardized mean differences: SMD) of the lumbar spine (LS) femoral neck (FN) and/or total hip were considered as outcome measures. After subgroup categorization, statistical methods were used to combine data and compare subgroups. Seventy-five studies were included. The pooled number of participants was 5,300 (intervention group: n = 2,901, control group: n = 2,399). The pooled estimate of random effect analysis was SMD = 0.37, 95%-CI: 0.25–0.50, SMD = 0.33, 95%-CI: 0.23–0.43, and SMD = 0.40, 95%-CI: 0.28–0.51 for LS, FN, and total Hip-BMD, respectively. In the present meta-analysis, there was a significant (p < 0.001), but rather low effect (SMD = 0.33–0.40) of exercise on BMD at LS and proximal femur. A large variation among the single study findings was observed, with highly effective studies but also studies that trigger significant negative results. These findings can be largely attributed to differences among the exercise protocols of the studies. Findings suggest that the true effect of exercise on BMD is diluted by a considerable amount of studies with inadequate exercise protocols.

Authors with CRIS profile

Involved external institutions

Hochschule Furtwangen Germany (DE) University of Bologna / Università di Bologna Italy (IT) University of Ulster United Kingdom (GB) Helsingin yliopisto / University of Helsinki Finland (FI) Laurea University of Applied Sciences Finland (FI)

How to cite

APA:

Shojaa, M., von Stengel, S., Schöne, D., Kohl, M., Barone, G., Bragonzoni, L.,... Kemmler, W. (2020). Effect of exercise training on bone mineral density in post-menopausal women: A systematic review and meta-analysis of intervention studies. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.00652

MLA:

Shojaa, Mahdieh, et al. "Effect of exercise training on bone mineral density in post-menopausal women: A systematic review and meta-analysis of intervention studies." Frontiers in Physiology 11 (2020).

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