A Single-Molecule View on Cellular and Viral RNA Synthesis

Ostrofet E, Papini FS, Malinen AM, Dulin D (2019)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2019

Edited Volumes: Biophysics of RNA-Protein Interactions

Series: Biological and Medical Physics, Biomedical Engineering

Pages Range: 109-141

DOI: 10.1007/978-1-4939-9726-8_6

Abstract

RNA synthesis is at the heart of gene expression, the RNA products serving in cellular organisms as protein blueprints, structural/functional components of molecular machines or regulators of gene expression, and as the genetic material of nascent RNA viruses. Because of its importance, transcription—the process converting DNA to RNA—has been extensively studied at the single-molecule level; first in bacterial systems and quickly after in other domains of life. RNA replication in RNA viruses has recently become an important research topic in the single-molecule field, aiming not only to uncover its versatile mechanisms but also to develop new therapeutics against these devastating human pathogens. Here, we summarize the recent advances in cellular and viral RNA production using in vitro single-molecule techniques.

Authors with CRIS profile

Eugeniu Ostrofet Interdisziplinäres Zentrum für Klinische Forschung IZKF Nachwuchsgruppe 2 Prof. Dr. Dulin David Dulin Interdisziplinäres Zentrum für Klinische Forschung IZKF Nachwuchsgruppe 2 Prof. Dr. Dulin

Involved external institutions

University of Turku / Turun yliopisto FI Finland (FI)

How to cite

APA:

Ostrofet, E., Papini, F.S., Malinen, A.M., & Dulin, D. (2019). A Single-Molecule View on Cellular and Viral RNA Synthesis. In Chirlmin Joo, David Rueda (Eds.), Biophysics of RNA-Protein Interactions. (pp. 109-141).

MLA:

Ostrofet, Eugeniu, et al. "A Single-Molecule View on Cellular and Viral RNA Synthesis." Biophysics of RNA-Protein Interactions. Ed. Chirlmin Joo, David Rueda, 2019. 109-141.

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