Effects of bacteria on male fertility: Spermatogenesis and sperm function

Oghbaei H, Rastgar Rezaei Y, Nikanfar S, Zarezadeh R, Sadegi M, Latifi Z, Nouri M, Fattahi A, Ahmadi Y, Bleisinger N (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

Life Sciences Elsevier

Book Volume: 256

Article Number: 117891

DOI: 10.1016/j.lfs.2020.117891

Abstract

Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect of bacteria on sperm and their mechanism of action. Interestingly, bacteria can induce different damages on sperm cells such as DNA fragmentation, cell membrane peroxidation, and acrosome impairment. Such negative effects can be mediated by bacteria-secreted toxins and metabolites or by direct attachment of bacteria on the sperm cells and subsequent activation of signaling pathways related to oxidative stress, apoptosis, and inflammation. These bacteria-induced changes can impair semen parameters and subsequently cause infertility. Given the significant destructive effect of some bacteria on sperm function and male fertility, in this study, we reviewed the impact of male urogenital bacteria on spermatogenesis and sperm functions as well as the underlying mechanisms by which the bacteria can damage sperm.

Authors with CRIS profile

Nathalie Bleisinger Professur für Experimentelle Reproduktionsmedizin

Involved external institutions

Tabriz University of Medical Sciences (TBZMED) / دانشگاه علوم پزشکی تبریز IR Iran, Islamic Republic of (IR) Sina Hospital IR Iran, Islamic Republic of (IR)

How to cite

APA:

Oghbaei, H., Rastgar Rezaei, Y., Nikanfar, S., Zarezadeh, R., Sadegi, M., Latifi, Z.,... Bleisinger, N. (2020). Effects of bacteria on male fertility: Spermatogenesis and sperm function. Life Sciences, 256. https://doi.org/10.1016/j.lfs.2020.117891

MLA:

Oghbaei, Hajar, et al. "Effects of bacteria on male fertility: Spermatogenesis and sperm function." Life Sciences 256 (2020).

BibTeX: Download