Tumor handling of early-stage cervical cancer: A literature analysis of villoglandular adenocarcinoma of the cervix

Dietl A, Aumann K, Beckmann M (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

Anticancer Research International Institute of Anticancer Research (IIAR)

Book Volume: 40

Pages Range: 3049-3053

Journal Issue: 6

DOI: 10.2196/10.21873/anticanres.14285

Abstract

Background/Aim: Recent studies have demonstrated the inferior overall survival outcomes of patients with early-stage cervical cancer who undergo minimally invasive surgery (MIS). One possible explanation for these unexpected results is intraoperative tumor manipulation. Materials and Methods: Considering this hypothesis, we have reviewed the literature on the oncological outcomes of patients with villoglandular adenocarcinoma (VGA) of the cervix, an uncommon variant of cervical cancer that has an excellent prognosis. Results: VGA generally presents as an exophytic mass arising from the endocervix. In a systematic review, we identified 221 patients treated surgically for VGA (FIGO stage Ia-Ib1). Of these, 11 developed recurrence, and four died. The recurrence sites in 8 cases were the pelvis (n=3), vaginal cuff (n=3), episiotomy scar (n=1), and cervix (n=1). Furthermore, 23 VGA-patients were treated by MIS, four experienced recurrence, and one died. Three intraabdominal metastases after MIS were reported. Conclusion: Excessive tumor-handling during MIS or manipulations, e.g. cervix-dilation (during delivery), can worsen the otherwise excellent prognosis.

Authors with CRIS profile

Anna Dietl Department of Obstetrics and Gynaecology Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde

Involved external institutions

Albert-Ludwigs-Universität Freiburg DE Germany (DE)

How to cite

APA:

Dietl, A., Aumann, K., & Beckmann, M. (2020). Tumor handling of early-stage cervical cancer: A literature analysis of villoglandular adenocarcinoma of the cervix. Anticancer Research, 40(6), 3049-3053. https://doi.org/10.2196/10.21873/anticanres.14285

MLA:

Dietl, Anna, Konrad Aumann, and Matthias Beckmann. "Tumor handling of early-stage cervical cancer: A literature analysis of villoglandular adenocarcinoma of the cervix." Anticancer Research 40.6 (2020): 3049-3053.

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