Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response

Wilmes D, Schui D, Held J, Ackermann S, Geipel U, Emrich K, Winkelmann EJ, Rickerts V (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Medical Mycology Case Reports Elsevier

Book Volume: 29

Pages Range: 25-28

DOI: 10.1016/j.mmcr.2020.05.007

Abstract

We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the complement fixation test after two years. The (1 → 3)-ß-D-glucan levels normalised after two years without increase after cessation of antifungal therapy. Biomarkers in serum may guide treatment decisions in disseminated coccidioidomycosis.

Authors with CRIS profile

Jürgen Held Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene

Involved external institutions

Bioscientia Healthcare Group DE Germany (DE) Robert Koch-Institut (RKI) DE Germany (DE)

How to cite

APA:

Wilmes, D., Schui, D., Held, J., Ackermann, S., Geipel, U., Emrich, K.,... Rickerts, V. (2020). Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response. Medical Mycology Case Reports, 29, 25-28. https://doi.org/10.1016/j.mmcr.2020.05.007

MLA:

Wilmes, Dunja, et al. "Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response." Medical Mycology Case Reports 29 (2020): 25-28.

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