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Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers

Misaka S, Abe O, Ono T, Ono Y, Ogata H, Miura I, Shikama Y, Fromm M, Yabe H, Shimomura K (2020)

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Publication Type: Journal article

Publication year: 2020

Journal

DOI: 10.1111/bcp.14315

Abstract

Aims: The aim of this study was to investigate the effects of a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics. Methods: In a randomized 3-phase crossover study, 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingestion of brewed GT, or with water in a volume of 150 mL. Results: Geometric mean ratio with 90% confidence interval for nadolol AUC0–48 was 0.371 (0.303–0.439) with concomitant GT. In addition, ingestion of GT 1 hour before nadolol administration resulted in a significant reduction of nadolol AUC0–48 with geometric mean ratio of 0.536 (0.406–0.665). There were no differences in time to maximal plasma concentration and renal clearance of nadolol among groups. Conclusion: These results suggest that single concomitant ingestion of GT substantially decreases plasma concentrations of nadolol. Moreover, the reduction in nadolol bioavailability could persist for at least 1 hour after drinking a cup of GT.

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APA:

Misaka, S., Abe, O., Ono, T., Ono, Y., Ogata, H., Miura, I.,... Shimomura, K. (2020). Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers. British Journal of Clinical Pharmacology. https://dx.doi.org/10.1111/bcp.14315

MLA:

Misaka, Shingen, et al. "Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers." British Journal of Clinical Pharmacology (2020).

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