A novel natural GRAS-grade enteric coating for pharmaceutical and nutraceutical products

Khoder M, Schropp V, Zeitler S, Pereira B, Habashy R, Royall PG, Wang JTW, Alhnan MA (2020)

Publication Type: Journal article

Publication year: 2020

Journal

International Journal of Pharmaceutics Elsevier

Book Volume: 584

Article Number: 119392

DOI: 10.1016/j.ijpharm.2020.119392

Abstract

In this study, enteric coatings based exclusively on naturally occurring ingredients were reported. Alginate (Alg) and pectin (Pec) blends with or without naturally occurring glyceride, glycerol monostearate (GMS), were initially used to produce solvent-casted films. Incorporating GMS in the natural polymeric films significantly enhanced the acid-resistance properties in gastric medium. Theophylline tablets coated with Alg-Pec blends without GMS disintegrated shortly after incubation in gastric medium (pH 1.2), leading to a premature and complete release of theophylline. Interestingly, tablets coated with Alg-Pec blends that contain the natural glyceride (GMS) resisted the gastric environment for 2 h with minimal drug release (<5%) and disintegrated rapidly following introduction to the intestinal medium, allowing a fast and complete drug release. Furthermore, the coating system proved to be stable for six months under accelerated conditions. These findings are particularly appealing to nutraceutical industry as they provide the foundation to produce naturally-occurring GRAS based enteric coatings.

Authors with CRIS profile

Verena Schropp Lehrstuhl für Mikroskopische Anatomie und Molekulare Zellbiologie

Involved external institutions

King’s College London GB United Kingdom (GB) University of Central Lancashire (UCLan) GB United Kingdom (GB) Kingston University GB United Kingdom (GB)

How to cite

APA:

Khoder, M., Schropp, V., Zeitler, S., Pereira, B., Habashy, R., Royall, P.G.,... Alhnan, M.A. (2020). A novel natural GRAS-grade enteric coating for pharmaceutical and nutraceutical products. International Journal of Pharmaceutics, 584. https://dx.doi.org/10.1016/j.ijpharm.2020.119392

MLA:

Khoder, Mouhamad, et al. "A novel natural GRAS-grade enteric coating for pharmaceutical and nutraceutical products." International Journal of Pharmaceutics 584 (2020).

BibTeX: Download