Expression of calcitonin receptor-like receptor in human vascular tumours.

Hagner S, Stahl U, Grimm T, Stürzl M, Lang RE (2006)

Publication Status: Published

Publication Type: Journal article

Publication year: 2006

Journal

Journal of Clinical Pathology BMJ Publishing Group

Book Volume: 59

Pages Range: 1104-7

Journal Issue: 10

DOI: 10.1136/jcp.2005.026930

Abstract

Background: Vascular tumours such as Kaposi’s sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.
Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.
Methods: CRLR expression was investigated in several specimens of Kaposi’s sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.
Results: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium.
Conclusions: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.

Authors with CRIS profile

Michael Stürzl Professur für Molekulare und Experimentelle Chirurgie

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) MVZ Institut für Pathologie, Zytologie und Molekularpathologie GbR DE Germany (DE) Philipps-Universität Marburg DE Germany (DE)

How to cite

APA:

Hagner, S., Stahl, U., Grimm, T., Stürzl, M., & Lang, R.E. (2006). Expression of calcitonin receptor-like receptor in human vascular tumours. Journal of Clinical Pathology, 59(10), 1104-7. https://doi.org/10.1136/jcp.2005.026930

MLA:

Hagner, Stefanie, et al. "Expression of calcitonin receptor-like receptor in human vascular tumours." Journal of Clinical Pathology 59.10 (2006): 1104-7.

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