Oncogenesis in HIV-infection.

Albini A, Aluigi M, Benelli R, Biberfeld P, Blasig C, Calabro M, Calvo F, Chieco-Bianchi L, Corbellino M, Del Mistro A, Ekman M, Favero A, Hofschneider PH, Kaaya E, Lebbe C, Morel P, Neipel F, Noonan D, Parravicini C, Repetto L, Schalling M, Stürzl M, Tschachler E (1996)

Publication Status: Published

Publication Type: Journal article

Publication year: 1996


Book Volume: 9

Pages Range: 5-8

Journal Issue: 1

DOI: 10.3892/ijo.9.1.5


The presence of human Kaposi's sarcoma associated herpesvirus-like sequences (KSHV) was examined in different epidemiological variants of Kaposi's sarcoma (KS) and in KS-derived cell cultures by polymerase chain reaction (PCR). KSHV DNA was present in all tumor biopsies of AIDS-associated KS (59 biopsies), endemic KS (26 biopsies; 21 African endemic KS, 5 Greek endemic KS), sporadic/classical KS (28 biopsies) and post-transplant/iatrogenic KS (6 of 7 biopsies). On the contrary, these sequences were only detected rarely in non-involved skin of KS patients (3 positive specimens of 12), in the peripheral blood mononuclear cells of HIV-infected patients (3 positive specimens of 54) and in lymphoma-biopsies (3 positive specimens of 47). Cell cultures derived from KS skin lesions were positive for KSHV DNA only in the first two passages. However, two longer-term positive cultures from a biopsy of a patient affected with sporadic KS and a biopsy of a patient affected with epidemic KS was identified. A strong association of KSHV with KS tissue was observed in all the different epidemiological variants of KS. Long-term positive KS-derived cell cultures will be an important tool to study the herpesvirus-like agent and to investigate its functional role in the initiation and progression of KS.

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Albini, A., Aluigi, M., Benelli, R., Biberfeld, P., Blasig, C., Calabro, M.,... Tschachler, E. (1996). Oncogenesis in HIV-infection. International Journal of Oncology, 9(1), 5-8. https://doi.org/10.3892/ijo.9.1.5


Albini, Adriana, et al. "Oncogenesis in HIV-infection." International Journal of Oncology 9.1 (1996): 5-8.

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