The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection

Fernandes VE, Ercoli G, Bénard A, Brandl C, Fahnenstiel H, Müller-Winkler J, Denny P, Nitschke L, Andrew PW, Weber G (2020)

Publication Type: Journal article

Publication year: 2020

Journal

PLoS Pathogens Public Library of Science

Book Volume: 16

Pages Range: e1008464-

Journal Issue: 4

DOI: 10.1371/journal.ppat.1008464

Abstract

Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease.

Authors with CRIS profile

Carolin Brandl Professur für Genetik Lars Nitschke Professur für Genetik Georg Weber Department of Surgery

Involved external institutions

University of Leicester GB United Kingdom (GB) MRC Harwell Institute GB United Kingdom (GB)

How to cite

APA:

Fernandes, V.E., Ercoli, G., Bénard, A., Brandl, C., Fahnenstiel, H., Müller-Winkler, J.,... Weber, G. (2020). The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLoS Pathogens, 16(4), e1008464-. https://doi.org/10.1371/journal.ppat.1008464

MLA:

Fernandes, Vitor E., et al. "The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection." PLoS Pathogens 16.4 (2020): e1008464-.

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