The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection

Fernandes VE, Ercoli G, Bénard A, Brandl C, Fahnenstiel H, Müller-Winkler J, Denny P, Nitschke L, Andrew PW, Weber G (2020)


Publication Type: Journal article

Publication year: 2020

Journal

Book Volume: 16

Pages Range: e1008464-

Journal Issue: 4

DOI: 10.1371/journal.ppat.1008464

Abstract

Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease.

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How to cite

APA:

Fernandes, V.E., Ercoli, G., Bénard, A., Brandl, C., Fahnenstiel, H., Müller-Winkler, J.,... Weber, G. (2020). The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLoS Pathogens, 16(4), e1008464-. https://dx.doi.org/10.1371/journal.ppat.1008464

MLA:

Fernandes, Vitor E., et al. "The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection." PLoS Pathogens 16.4 (2020): e1008464-.

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