Naganawa S, Nakane T, Kawai H, Taoka T, Kawaguchi H, Maruyama K, Murata K, Körzdörfer G, Pfeuffer J, Nittka M, Sone M (2020)
Publication Type: Journal article
Publication year: 2020
Book Volume: 19
Pages Range: 141-146
Journal Issue: 2
DOI: 10.2463/mrms.mp.2019-0048
Purpose: It has been reported that leakage of intravenously administered gadolinium-based contrast agents (IV-GBCAs) into the cerebrospinal fluid (CSF) from the cortical veins even in healthy subjects can be detected using a highly sensitive pulse sequence such as heavily T2-weighted 3D fluid-attenuated inversion recovery and 3D-real inversion recovery (IR). The purpose of this study was to evaluate the feasibility of MR fingerprinting to detect GBCA leakage from the cortical veins after IV-GBCA. Materials: Fourteen patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (39–79 years old) were included. The real IR images as well as MR fingerprinting images were obtained at 4 h after IV-GBCA. T1 and T2 values were obtained using MR fingerprinting and analyzed in ROIs covering intense GBCA leakage, and non-leakage areas of the CSF as determined on real IR images. The scan time for real IR imaging was 10 min and that for MR fingerprinting was 41 s. Results: The mean T1 value of the ROI in the area of GBCA leakage was 2422 ± 261 ms and that in the non-leakage area was 3851 ± 235 ms (P < 0.01). There was no overlap between the T1 values in the area of GBCA leakage and those in the non-leakage area. The mean T2 value in the area of GBCA leakage was 319 ± 90 ms and that in the non-leakage area was 670 ± 166 ms (P < 0.01). There was some overlap between the T2 values in the area of GBCA leakage and those in the non-leakage area. Conclusion: Leaked GBCA from the cortical veins into the surrounding CSF can be detected using MR fingerprinting obtained in <1 min.
APA:
Naganawa, S., Nakane, T., Kawai, H., Taoka, T., Kawaguchi, H., Maruyama, K.,... Sone, M. (2020). Detection of iv-gadolinium leakage from the cortical veins into the CSF using MR fingerprinting. Magnetic Resonance in Medical Sciences, 19(2), 141-146. https://dx.doi.org/10.2463/mrms.mp.2019-0048
MLA:
Naganawa, Shinji, et al. "Detection of iv-gadolinium leakage from the cortical veins into the CSF using MR fingerprinting." Magnetic Resonance in Medical Sciences 19.2 (2020): 141-146.
BibTeX: Download