Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy

Berghoff M, Kilo S, Hilz MJ, Freeman RL (2006)

Publication Status: Published

Publication Type: Other publication type

Publication year: 2006

Journal

Muscle & Nerve Wiley-Blackwell

Publisher: WILEY

Book Volume: 33

Pages Range: 494-499

Journal Issue: 4

DOI: 10.1002/mus.20497

Abstract

It is not known whether C-fiber functional subclasses are differentially affected by diabetes mellitus or whether the patterns of C-fiber dysfunction are different between type 1 and type 2 diabetes. We therefore examined efferent sympathetic sudomotor and primary afferent nociceptor C-fiber function in diabetic patients. Acetylcholine (10%) was used to evoke C-fiber (axon-reflex)-mediated responses. The nociceptor (flare) response was measured using a laser Doppler device. The sudomotor response was quantified with silastic imprints. The nociceptor C-fiber-mediated flare response was reduced in type 2 diabetic patients (P < 0.008) but was similar to controls in type 1 diabetic patients. The sympathetic C-fiber-mediated responses, including sweat volume (P < 0.05) and the number of activated sweat glands (P = 0.003), were increased in patients with type 1 diabetes. There also was a trend toward a larger axon-reflex sweat area in patients with type 1 diabetes (P = 0.09). No differences in these sweat responses were found in patients with type 2 diabetes compared to controls. These findings suggest that the functional abnormalities in diabetic peripheral neuropathy are not homogeneous and that C-fiber subclasses are differentially affected in type 1 and 2 diabetes mellitus.

Authors with CRIS profile

Sonja Kilo Lehrstuhl für Arbeits-, Sozial- und Umweltmedizin Max-Josef Hilz Medizinische Fakultät

Involved external institutions

Harvard University US United States (USA) (US) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE)

How to cite

APA:

Berghoff, M., Kilo, S., Hilz, M.-J., & Freeman, R.L. (2006). Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy. WILEY.

MLA:

Berghoff, Martin, et al. Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy. WILEY, 2006.

BibTeX: Download