Oro-dental pathologies in acromegaly
Kreitschmann-Andermahr I, Kohlmann J, Kleist B, Hirschfelder U, Buslei R, Buchfelder M, Siegel S (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 60
Pages Range: 323-328
Journal Issue: 2
DOI: 10.1007/s12020-018-1571-y
Abstract
PURPOSE: Oro-dental pathologies (ODP) such as enlargement of the tongue, mandibular prognathism, and spaced teeth are characteristic features of acromegaly. Their frequency of occurrence during the course of the disease is largely unresolved. Purpose of this study was to assess ODP and oro-dental treatments in patients with acromegaly with regard to the length of the diagnostic process, tumor histology, and quality of life (QoL). METHODS: Single-center retrospective survey study using questionnaires on dental symptoms, diagnostic process, and treatment in patients with acromegaly operated on a growth hormone-secreting pituitary adenoma. The association between ODP and QoL was assessed using the Short-Form 36 (SF-36) Health Survey. RESULTS: 145/314 patients completed the questionnaires. 80.7% were affected by any ODP, most frequently enlargement of the tongue (57.9%), spaced teeth (42.8%), mandibular growth (24.1%), and mandibular prognathism (22.1%). ODP were significantly more frequent in patients with sparsely vs. densely granulated adenomas (p = 0.045). Early diagnosis within 2 years was associated with significantly fewer ODP than later diagnosis (68.5 vs. 87.2%, p = 0.009). Treatments included dental crowns (16.6%), dental bridges (12.4%), dental implants (9.7%), dental prostheses (3.4%), orthodontal (i.e., braces, 6.9%), and surgical correction of the teeth (2.1%). Physical QoL was significantly lower in patients with ODP than in those without (p = 0.014). CONCLUSION: In our large series of patients, four of five patients were affected by ODP at any time during the course of the disease. The results highlight the importance of early identification and treatment of oro-dental problems in patients with acromegaly as hallmarks of the disease.
Authors with CRIS profile
Johannes Kohlmann
Department of Neurosurgery
Ursula Hirschfelder
Medizinische Fakultät
Michael Buchfelder
Lehrstuhl für Neurochirurgie
Involved external institutions
Germany (DE)How to cite
APA:
Kreitschmann-Andermahr, I., Kohlmann, J., Kleist, B., Hirschfelder, U., Buslei, R., Buchfelder, M., & Siegel, S. (2018). Oro-dental pathologies in acromegaly. Endocrine, 60(2), 323-328. https://doi.org/10.1007/s12020-018-1571-y
MLA:
Kreitschmann-Andermahr, Ilonka, et al. "Oro-dental pathologies in acromegaly." Endocrine 60.2 (2018): 323-328.
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