Radical intended surgery for highly selected stage IV neuroendocrine neoplasms G3

Merola E, Falconi M, Rinke A, Staettner S, Krendl F, Partelli S, Andreasi V, Gress TM, Pascher A, Arsenic R, Doglioni C, Kaemmerer D, Wiedenmann B, Pavel ME (2020)

Publication Type: Journal article

Publication year: 2020

Journal

American Journal of Surgery Elsevier

DOI: 10.1016/j.amjsurg.2020.03.009

Abstract

Background: Stage IV gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) G3 are the NENs with the worst prognosis. According to ENETS guidelines, platinum-based chemotherapy is the standard treatment for this population. Surgery is only considered in highly selected “resectable” NENs with usually lower Ki67. However, the role of surgery with curative intent has been poorly investigated. Objective: To describe, in a retrospective series of stage IV GEP-NENs G3, overall survival (OS) and recurrence-free survival (RFS) rates after curatively intended surgery. Methods: Multicenter analysis of stage IV GEP-NENs G3 receiving radical resection (R0/R1) from 2007 to 2017, with minimum post-surgical follow-up time of 3 months. Results: Fifteen patients from 6 NEN referral centers, with median follow-up of 29 months (8-86), were included. Eight cases had a neuroendocrine carcinoma (NEC) and 7 a neuroendocrine tumor G3 (NET G3). Median OS after radical surgery was 59 months. All patients recurred, with a median RFS of 8 months. Conclusions: Radical surgery might be considered for highly selected stage IV GEP-NENs G3. Larger series are needed to confirm these results.

Authors with CRIS profile

Marianne Ellen Pavel Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Involved external institutions

Università Vita-Salute San Raffaele (UniSR) IT Italy (IT) Medizinische Universität Innsbruck AT Austria (AT) Universitätsklinikum Münster DE Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Ospedale San Raffaele (früher: Centro San Raffaele del Monte Tabor Foundation) IT Italy (IT) Zentralklinikum Bad Berka DE Germany (DE)

How to cite

APA:

Merola, E., Falconi, M., Rinke, A., Staettner, S., Krendl, F., Partelli, S.,... Pavel, M.E. (2020). Radical intended surgery for highly selected stage IV neuroendocrine neoplasms G3. American Journal of Surgery. https://doi.org/10.1016/j.amjsurg.2020.03.009

MLA:

Merola, Elettra, et al. "Radical intended surgery for highly selected stage IV neuroendocrine neoplasms G3." American Journal of Surgery (2020).

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