Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation
Clahsen T, Büttner C, Hatami N, Reis A, Cursiefen C (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 9
Journal Issue: 2
DOI: 10.3390/jcm9020479
Abstract
Under normal conditions, the cornea, being the transparent "windscreen" of the eye, is free of both blood and lymphatic vessels. However, various diseases of the eye, like infections, can interfere with the balance between promoting and inhibiting factors, which leads to ingrowth of blood and lymphatic vessels. The newly formed lymphatic vessels increase the risk of graft rejection after subsequent corneal transplantation. Corneal transplantation is one of the most commonly performed transplantations worldwide, with more than 40,000 surgeries per year in Europe. To date, various anti-hem- and anti-lymphangiogenic treatment strategies have been developed specifically for the corneal vascular endothelial growth factor (VEGF) pathway. Currently, however, no treatment strategies are clinically available to specifically modulate lymphangiogenesis. In this review, we will give an overview about endogenous regulators of hem- and lymphangiogenesis and discuss potential new strategies for targeting pathological lymphangiogenesis. Furthermore, we will review recently identified modulators and demonstrate that the cornea is a suitable model for the identification of novel endogenous modulators of lymphangiogenesis. The identification of novel modulators of lymphangiogenesis and a better understanding of the signaling pathways involved will contribute to the development of new therapeutic targets for the treatment of pathological lymphangiogenesis. This, in turn, will improve graft rejection, not only for the cornea.
Authors with CRIS profile
Christian Büttner
Lehrstuhl für Humangenetik
André Wiesmann da Silva Reis
Lehrstuhl für Humangenetik
Involved external institutions
Germany (DE)How to cite
APA:
Clahsen, T., Büttner, C., Hatami, N., Reis, A., & Cursiefen, C. (2020). Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation. Journal of Clinical Medicine, 9(2). https://doi.org/10.3390/jcm9020479
MLA:
Clahsen, Thomas, et al. "Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation." Journal of Clinical Medicine 9.2 (2020).
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